Next Article in Journal
View Point: Semaphorin-3E: An Emerging Modulator of Natural Killer Cell Functions?
Previous Article in Journal
Oxidative Stress in Cardiovascular Diseases: Involvement of Nrf2 Antioxidant Redox Signaling in Macrophage Foam Cells Formation
Previous Article in Special Issue
The Emerging Role of the Major Histocompatibility Complex Class I in Amyotrophic Lateral Sclerosis
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2017, 18(11), 2338; doi:10.3390/ijms18112338

Recipient HLA-G +3142 CC Genotype and Concentrations of Soluble HLA-G Impact on Occurrence of CMV Infection after Living-Donor Kidney Transplantation

1
Department of Infectious Diseases, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany
2
Institute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany
3
Department of Nephrology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany
4
Institute for Virology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany
*
Author to whom correspondence should be addressed.
Received: 21 September 2017 / Revised: 29 October 2017 / Accepted: 31 October 2017 / Published: 5 November 2017
(This article belongs to the Special Issue Major Histocompatibility Complex)
View Full-Text   |   Download PDF [994 KB, uploaded 6 November 2017]   |  

Abstract

The expression modulation of the immunosuppressive non-classical Human leukocyte antigen-G (HLA-G) molecule and its soluble isoforms is an immune evasion strategy being deployed by cytomegalovirus (CMV). The +3142 C>G single nucleotide polymorphism (SNP) located within the 3′ untranslated region (3′UTR) is of crucial importance for the regulation of HLA-G expression. Therefore, we analyzed the influence of the +3142 C>G HLA-G SNP on the occurrence of CMV infection in a cohort of 178 living-donor kidney recipients and their 178 corresponding donors. In addition, soluble HLA-G (sHLA-G) levels were quantified before and after transplantation. The presence of the HLA-G +3142 CC genotype in recipients, but not donors of our cohort as along with elevated sHLA-G levels (≥ 6.1 ng/mL) were associated with higher susceptibility to CMV infection after transplantation. Our results provided evidence that i) HLA-G is implicated in the establishment of CMV after living-donor kidney transplantation and ii) recipient HLA-G +3142 CC genotype and sHLA-G concentration levels could represent important predictive risk markers for CMV infection. View Full-Text
Keywords: Human leukocyte antigen-G; HLA-G 3′UTR Polymorphisms; Living Kidney Transplantation; Cytomegalovirus Human leukocyte antigen-G; HLA-G 3′UTR Polymorphisms; Living Kidney Transplantation; Cytomegalovirus
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Guberina, H.; Tomoya Michita, R.; Dolff, S.; Bienholz, A.; Trilling, M.; Heinemann, F.M.; Horn, P.A.; Kribben, A.; Witzke, O.; Rebmann, V. Recipient HLA-G +3142 CC Genotype and Concentrations of Soluble HLA-G Impact on Occurrence of CMV Infection after Living-Donor Kidney Transplantation. Int. J. Mol. Sci. 2017, 18, 2338.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top