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Int. J. Mol. Sci. 2017, 18(11), 2337; https://doi.org/10.3390/ijms18112337

View Point: Semaphorin-3E: An Emerging Modulator of Natural Killer Cell Functions?

Department of Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0T5, Canada
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Received: 29 September 2017 / Revised: 21 October 2017 / Accepted: 1 November 2017 / Published: 5 November 2017
(This article belongs to the Special Issue Natural Killer (NK) Cells)
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Abstract

Semaphorin-3E (Sema-3E) is a member of a large family of proteins originally identified as axon guidance cues in neural development. It is expressed in different cell types, such as immune cells, cancer cells, neural cells, and epithelial cells. Subsequently, dys-regulation of Sema-3E expression has been reported in various biological processes that range from cancers to autoimmune and allergic diseases. Recent work in our laboratories revealed a critical immunoregulatory role of Sema-3E in experimental allergic asthma. We further speculate possible immune modulatory function(s) of Sema-3E on natural killer (NK) cells. View Full-Text
Keywords: semaphorins; semaphorin-3E; plexins; nervous system; cardiovascular; allergic asthma; cancer; natural killer cells semaphorins; semaphorin-3E; plexins; nervous system; cardiovascular; allergic asthma; cancer; natural killer cells
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Alamri, A.; Soussi Gounni, A.; Kung, S.K.P. View Point: Semaphorin-3E: An Emerging Modulator of Natural Killer Cell Functions? Int. J. Mol. Sci. 2017, 18, 2337.

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