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Int. J. Mol. Sci. 2017, 18(11), 2300; doi:10.3390/ijms18112300

Which Plant Proteins Are Involved in Antiviral Defense? Review on In Vivo and In Vitro Activities of Selected Plant Proteins against Viruses

Department of Molecular Virology, Institute of Experimental Biology, Faculty of Biology, Adam Mickiewicz University in Poznań, 61-614 Poznań, Poland
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Received: 26 September 2017 / Revised: 24 October 2017 / Accepted: 27 October 2017 / Published: 1 November 2017
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Plants have evolved a variety of defense mechanisms to tackle virus attack. Endogenous plant proteins can function as virus suppressors. Different types of proteins mediate defense responses against plant viruses. Pathogenesis-related (PR) proteins are activated upon pathogen infections or in different stress situations and their production is one of many components in plant defense. Ribosome-inactivating proteins (RIPs) suppress translation by enzymatically damaging ribosomes and they have been found to have antiviral activity. RNA-binding proteins (RBPs) bind to target RNAs via specialized RNA-binding domain and can directly or indirectly function in plant defense system against RNA viruses. Proteins involved in silencing machinery, namely Dicer-like (DCL) proteins, Argonaute (AGO) proteins, and RNA-dependent RNA polymerases (RDRs) confer innate antiviral defense in plants as they are able to degrade foreign RNA of viral origin. This review aims to provide a comprehensive and up-to-date picture of plant proteins participating in antiviral defense. As a result we discuss proteins conferring plant antiviral resistance and their potential future applications in different fields of life including agriculture and medicine. View Full-Text
Keywords: plant defense; antiviral proteins; ribosome-inactivating proteins; RNA-binding proteins; pathogenesis-related proteins; dicer-like proteins; Argonaute proteins; plant virus; RNA silencing plant defense; antiviral proteins; ribosome-inactivating proteins; RNA-binding proteins; pathogenesis-related proteins; dicer-like proteins; Argonaute proteins; plant virus; RNA silencing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Musidlak, O.; Nawrot, R.; Goździcka-Józefiak, A. Which Plant Proteins Are Involved in Antiviral Defense? Review on In Vivo and In Vitro Activities of Selected Plant Proteins against Viruses. Int. J. Mol. Sci. 2017, 18, 2300.

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