Next Article in Journal
A Review on Konjac Glucomannan Gels: Microstructure and Application
Next Article in Special Issue
Diverse Effects of an Acetylcholinesterase Inhibitor, Donepezil, on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure
Previous Article in Journal
The Analysis of A Frequent TMPRSS3 Allele Containing P.V116M and P.V291L in A Cis Configuration among Deaf Koreans
Previous Article in Special Issue
Bioactivity of Olive Oil Phenols in Neuroprotection
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(11), 2247; doi:10.3390/ijms18112247

A Systematic Review of Neuroprotective Strategies during Hypovolemia and Hemorrhagic Shock

1
Department of Neurology, Jena University Hospital, 07747 Jena, Germany
2
Emergency Department, Jena University Hospital, 07747 Jena, Germany
3
Institute for Biochemistry II, Jena University Hospital, 07747 Jena, Germany
4
Orthopedic Department, Jena University Hospital, 07747 Jena, Germany
*
Author to whom correspondence should be addressed.
Received: 29 September 2017 / Revised: 23 October 2017 / Accepted: 24 October 2017 / Published: 26 October 2017
(This article belongs to the Special Issue Neuroprotective Strategies 2017)
View Full-Text   |   Download PDF [657 KB, uploaded 27 October 2017]   |  

Abstract

Severe trauma constitutes a major cause of death and disability, especially in younger patients. The cerebral autoregulatory capacity only protects the brain to a certain extent in states of hypovolemia; thereafter, neurological deficits and apoptosis occurs. We therefore set out to investigate neuroprotective strategies during haemorrhagic shock. This review was performed in accordance to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Before the start of the search, a review protocol was entered into the PROSPERO database. A systematic literature search of Pubmed, Web of Science and CENTRAL was performed in August 2017. Results were screened and evaluated by two researchers based on a previously prepared inclusion protocol. Risk of bias was determined by use of SYRCLE’s risk of bias tool. The retrieved results were qualitatively analysed. Of 9093 results, 119 were assessed in full-text form, 16 of them ultimately adhered to the inclusion criteria and were qualitatively analyzed. We identified three subsets of results: (1) hypothermia; (2) fluid therapy and/or vasopressors; and (3) other neuroprotective strategies (piracetam, NHE1-inhibition, aprotinin, human mesenchymal stem cells, remote ischemic preconditioning and sevoflurane). Overall, risk of bias according to SYRCLE’s tool was medium; generally, animal experimental models require more rigorous adherence to the reporting of bias-free study design (randomization, etc.). While the individual study results are promising, the retrieved neuroprotective strategies have to be evaluated within the current scientific context—by doing so, it becomes clear that specific promising neuroprotective strategies during states of haemorrhagic shock remain sparse. This important topic therefore requires more in-depth research. View Full-Text
Keywords: neuroprotective strategies; neuroprotection; brain damage; hypovolemia; shock; haemorrhage; bleeding; resuscitation neuroprotective strategies; neuroprotection; brain damage; hypovolemia; shock; haemorrhage; bleeding; resuscitation
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Nistor, M.; Behringer, W.; Schmidt, M.; Schiffner, R. A Systematic Review of Neuroprotective Strategies during Hypovolemia and Hemorrhagic Shock. Int. J. Mol. Sci. 2017, 18, 2247.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top