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Int. J. Mol. Sci. 2017, 18(10), 2184; https://doi.org/10.3390/ijms18102184

Vitamin D as a Novel Regulator of Tumor Metabolism: Insights on Potential Mechanisms and Implications for Anti-Cancer Therapy

Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
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Received: 30 September 2017 / Revised: 14 October 2017 / Accepted: 16 October 2017 / Published: 19 October 2017
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Abstract

1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the bioactive form of vitamin D, has been shown to possess significant anti-tumor potential. While most studies so far have focused on the ability of this molecule to influence the proliferation and apoptosis of cancer cells, more recent data indicate that 1,25(OH)2D3 also impacts energy utilization in tumor cells. In this article, we summarize and review the evidence that demonstrates the targeting of metabolic aberrations in cancers by 1,25(OH)2D3, and highlight potential mechanisms through which these effects may be executed. We shed light on the ability of this molecule to regulate metabolism-related tumor suppressors and oncogenes, energy- and nutrient-sensing pathways, as well as cell death and survival mechanisms such as autophagy. View Full-Text
Keywords: vitamin D; cancer; metabolism; autophagy; AMPK (AMP-activated protein kinase); mTOR (Mammalian target of rapamycin); TXNIP (Thioredoxin-interacting protein); p53; HIF1a (Hypoxia-inducible factor 1a); c-Myc vitamin D; cancer; metabolism; autophagy; AMPK (AMP-activated protein kinase); mTOR (Mammalian target of rapamycin); TXNIP (Thioredoxin-interacting protein); p53; HIF1a (Hypoxia-inducible factor 1a); c-Myc
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Abu el Maaty, M.A.; Wölfl, S. Vitamin D as a Novel Regulator of Tumor Metabolism: Insights on Potential Mechanisms and Implications for Anti-Cancer Therapy. Int. J. Mol. Sci. 2017, 18, 2184.

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