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Int. J. Mol. Sci. 2017, 18(11), 2252; https://doi.org/10.3390/ijms18112252

The Role of Toll-Like Receptors and Vitamin D in Cardiovascular Diseases—A Review

Department of Cardiology, Poznan University of Medical Sciences, Dluga Street ½, 61-848 Poznan, Poland
Received: 30 September 2017 / Revised: 24 October 2017 / Accepted: 25 October 2017 / Published: 27 October 2017
View Full-Text   |   Download PDF [881 KB, uploaded 27 October 2017]   |  

Abstract

Cardiovascular diseases are the leading cause of mortality worldwide. Therefore, a better understanding of their pathomechanisms and the subsequent implementation of optimal prophylactic and therapeutic strategies are of utmost importance. A growing body of evidence states that low-grade inflammation is a common feature for most of the cardiovascular diseases in which the contributing factors are the activation of toll-like receptors (TLRs) and vitamin D deficiency. In this article, available data concerning the association of cardiovascular diseases with TLRs and vitamin D status are reviewed, followed by a discussion of new possible approaches to cardiovascular disease management. View Full-Text
Keywords: toll-like receptors; vitamin D; cardiovascular diseases; atherosclerosis; inflammation toll-like receptors; vitamin D; cardiovascular diseases; atherosclerosis; inflammation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Adamczak, D.M. The Role of Toll-Like Receptors and Vitamin D in Cardiovascular Diseases—A Review. Int. J. Mol. Sci. 2017, 18, 2252.

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