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Int. J. Mol. Sci. 2017, 18(10), 2180; doi:10.3390/ijms18102180

G-Protein Dependent Signal Transduction and Ubiquitination in Dictyostelium

1
Department of Clinical and Biological Sciences, University of Turin, AOUS. Luigi, 10043 Orbassano TO, Italy
2
Department of Oncology, University of Turin, AOU S. Luigi, 10043 Orbassano TO, Italy
*
Author to whom correspondence should be addressed.
Received: 14 September 2017 / Revised: 12 October 2017 / Accepted: 16 October 2017 / Published: 19 October 2017
(This article belongs to the Special Issue Ubiquitin System)
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Abstract

Signal transduction through G-protein-coupled receptors (GPCRs) is central for the regulation of virtually all cellular functions, and it has been widely implicated in human diseases. These receptors activate a common molecular switch that is represented by the heterotrimeric G-protein generating a number of second messengers (cAMP, cGMP, DAG, IP3, Ca2+ etc.), leading to a plethora of diverse cellular responses. Spatiotemporal regulation of signals generated by a given GPCR is crucial for proper signalling and is accomplished by a series of biochemical modifications. Over the past few years, it has become evident that many signalling proteins also undergo ubiquitination, a posttranslational modification that typically leads to protein degradation, but also mediates processes such as protein-protein interaction and protein subcellular localization. The social amoeba Dictyostelium discoideum has proven to be an excellent model to investigate signal transduction triggered by GPCR activation, as cAMP signalling via GPCR is a major regulator of chemotaxis, cell differentiation, and multicellular morphogenesis. Ubiquitin ligases have been recently involved in these processes. In the present review, we will summarize the most significant pathways activated upon GPCRs stimulation and discuss the role played by ubiquitination in Dictyostelium cells. View Full-Text
Keywords: signal transduction; GPCRs; ubiquitination; cAMP; HERC1; HECT; Dictyostelium discoideum; mammals; TORC2 signal transduction; GPCRs; ubiquitination; cAMP; HERC1; HECT; Dictyostelium discoideum; mammals; TORC2
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Pergolizzi, B.; Bozzaro, S.; Bracco, E. G-Protein Dependent Signal Transduction and Ubiquitination in Dictyostelium. Int. J. Mol. Sci. 2017, 18, 2180.

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