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Int. J. Mol. Sci. 2017, 18(10), 2109; doi:10.3390/ijms18102109

Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer

1
Institute of Precision Medicine, Jining Medical University, Jining 272067, China
2
Department of Nursing, Health Professional College of Heilongjiang Province, Beian 164000, China
3
Department of Pathology, University of Illinois at Chicago, Chicago 60612, IL, USA
*
Author to whom correspondence should be addressed.
Received: 4 September 2017 / Revised: 23 September 2017 / Accepted: 30 September 2017 / Published: 8 October 2017
(This article belongs to the Special Issue Sphingolipids: Signals and Disease)
View Full-Text   |   Download PDF [737 KB, uploaded 9 October 2017]   |  

Abstract

Sphingosine kinase 1 (Sphk1) is a highly conserved lipid kinase that phosphorylates sphingosine to form sphingosine-1-phosphate (S1P). Growing studies have demonstrated that Sphk1 is overexpressed in various types of solid cancers and can be induced by growth factors, cytokines, and carcinogens, leading to the increase of S1P production. Subsequently, the increased Sphk1/S1P facilitates cancer cell proliferation, mobility, angiogenesis, invasion, and metastasis. Therefore, Sphk1/S1P signaling plays oncogenic roles. This review summarizes the features of Sphk1/S1P signaling and their functions in colorectal cancer cell growth, tumorigenesis, and metastasis, as well as the possible underlying mechanisms. View Full-Text
Keywords: sphingosine kinase 1; sphingosine-1-phosphate; colorectal cancer sphingosine kinase 1; sphingosine-1-phosphate; colorectal cancer
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Bao, Y.; Guo, Y.; Zhang, C.; Fan, F.; Yang, W. Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer. Int. J. Mol. Sci. 2017, 18, 2109.

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