Translational Implication of Galectin-9 in the Pathogenesis and Treatment of Viral Infection
AbstractThe interaction between galectin-9 and its receptor, Tim-3, triggers a series of signaling events that regulate immune responses. The expression of galectin-9 has been shown to be increased in a variety of target cells of many different viruses, such as hepatitis C virus (HCV), hepatitis B virus (HBV), herpes simplex virus (HSV), influenza virus, dengue virus (DENV), and human immunodeficiency virus (HIV). This enhanced expression of galectin-9 following viral infection promotes significant changes in the behaviors of the virus-infected cells, and the resulting events tightly correlate with the immunopathogenesis of the viral disease. Because the human immune response to different viral infections can vary, and the lack of appropriate treatment can have potentially fatal consequences, understanding the implications of galectin-9 is crucial for developing better methods for monitoring and treating viral infections. This review seeks to address how we can apply the current understanding of galectin-9 function to better understand the pathogenesis of viral infection and better treat viral diseases. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Lai, J.-H.; Luo, S.-F.; Wang, M.-Y.; Ho, L.-J. Translational Implication of Galectin-9 in the Pathogenesis and Treatment of Viral Infection. Int. J. Mol. Sci. 2017, 18, 2108.
Lai J-H, Luo S-F, Wang M-Y, Ho L-J. Translational Implication of Galectin-9 in the Pathogenesis and Treatment of Viral Infection. International Journal of Molecular Sciences. 2017; 18(10):2108.Chicago/Turabian Style
Lai, Jenn-Haung; Luo, Shue-Fen; Wang, Mei-Yi; Ho, Ling-Jun. 2017. "Translational Implication of Galectin-9 in the Pathogenesis and Treatment of Viral Infection." Int. J. Mol. Sci. 18, no. 10: 2108.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.