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Open AccessCommunication
Int. J. Mol. Sci. 2017, 18(10), 2033; doi:10.3390/ijms18102033

Spatiotemporal Control of Doxorubicin Delivery from “Stealth-Like” Prodrug Micelles

Supramolecular and Biomaterials Chemistry, Leiden Institute of Chemistry, Einsteinweg 55, 2333 CC Leiden, The Netherlands
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Received: 30 August 2017 / Revised: 14 September 2017 / Accepted: 18 September 2017 / Published: 22 September 2017
(This article belongs to the Special Issue Nanotechnology in Drug Delivery)
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Abstract

In the treatment of cancer, targeting of anticancer drugs to the tumor microenvironment is highly desirable. Not only does this imply accurate tumor targeting but also minimal drug release en route to the tumor and maximal drug release once there. Here we describe high-loading, “stealth-like” doxorubicin micelles as a pro-drug delivery system, which upon light activation, leads to burst-like doxorbicin release. Through this approach, we show precise spatiotemporal control of doxorubicin delivery to cells in vitro. View Full-Text
Keywords: micelles; prodrugs; doxorubicin; light activation micelles; prodrugs; doxorubicin; light activation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kong, L.; Poulcharidis, D.; Schneider, G.F.; Campbell, F.; Kros, A. Spatiotemporal Control of Doxorubicin Delivery from “Stealth-Like” Prodrug Micelles. Int. J. Mol. Sci. 2017, 18, 2033.

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