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Int. J. Mol. Sci. 2017, 18(10), 2028; doi:10.3390/ijms18102028

The Drosophila TRPA1 Channel and Neuronal Circuits Controlling Rhythmic Behaviours and Sleep in Response to Environmental Temperature

1
Department of Cell and Developmental Biology, University College London, London WC1E 6DE, UK
2
School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK
Current Address: Institute for Neuro- and Behavioral Biology, Westfälische Wilhelms University, 48149 Münster, Germany.
*
Author to whom correspondence should be addressed.
Received: 28 August 2017 / Revised: 13 September 2017 / Accepted: 14 September 2017 / Published: 3 October 2017
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Circadian Rhythms)
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Abstract

trpA1 encodes a thermosensitive transient receptor potential channel (TRP channel) that functions in selection of preferred temperatures and noxious heat avoidance. In this review, we discuss the evidence for a role of TRPA1 in the control of rhythmic behaviours in Drosophila melanogaster. Activity levels during the afternoon and rhythmic temperature preference are both regulated by TRPA1. In contrast, TRPA1 is dispensable for temperature synchronisation of circadian clocks. We discuss the neuronal basis of TRPA1-mediated temperature effects on rhythmic behaviours, and conclude that they are mediated by partly overlapping but distinct neuronal circuits. We have previously shown that TRPA1 is required to maintain siesta sleep under warm temperature cycles. Here, we present new data investigating the neuronal circuit responsible for this regulation. First, we discuss the difficulties that remain in identifying the responsible neurons. Second, we discuss the role of clock neurons (s-LNv/DN1 network) in temperature-driven regulation of siesta sleep, and highlight the role of TRPA1 therein. Finally, we discuss the sexual dimorphic nature of siesta sleep and propose that the s-LNv/DN1 clock network could play a role in the integration of environmental information, mating status and other internal drives, to appropriately drive adaptive sleep/wake behaviour. View Full-Text
Keywords: TRP channels; Drosophila; circadian clock; sleep; siesta; neuronal circuits; temperature sensing; temperature preference; temperature synchronisation; temperature entrainment TRP channels; Drosophila; circadian clock; sleep; siesta; neuronal circuits; temperature sensing; temperature preference; temperature synchronisation; temperature entrainment
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Roessingh, S.; Stanewsky, R. The Drosophila TRPA1 Channel and Neuronal Circuits Controlling Rhythmic Behaviours and Sleep in Response to Environmental Temperature. Int. J. Mol. Sci. 2017, 18, 2028.

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