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Int. J. Mol. Sci. 2017, 18(10), 2022; doi:10.3390/ijms18102022

Salmonella O48 Serum Resistance is Connected with the Elongation of the Lipopolysaccharide O-Antigen Containing Sialic Acid

1
Department of Microbiology, Institute of Genetics and Microbiology, University of Wrocław, 51-148 Wrocław, Poland
2
Department of Immunology of Infectious Diseases, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wrocław, Poland
3
Regional Centre of Transfusion Medicine and Blood Bank, 50-345 Wrocław, Poland
*
Authors to whom correspondence should be addressed.
Received: 7 August 2017 / Revised: 9 September 2017 / Accepted: 12 September 2017 / Published: 21 September 2017
(This article belongs to the Special Issue Lipopolysaccharides (LPSs))
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Abstract

Complement is one of the most important parts of the innate immune system. Some bacteria can gain resistance against the bactericidal action of complement by decorating their outer cell surface with lipopolysaccharides (LPSs) containing a very long O-antigen or with specific outer membrane proteins. Additionally, the presence of sialic acid in the LPS molecules can provide a level of protection for bacteria, likening them to human cells, a phenomenon known as molecular mimicry. Salmonella O48, which contains sialic acid in the O-antigen, is the major cause of reptile-associated salmonellosis, a worldwide public health problem. In this study, we tested the effect of prolonged exposure to human serum on strains from Salmonella serogroup O48, specifically on the O-antigen length. After multiple passages in serum, three out of four tested strains became resistant to serum action. The gas-liquid chromatography/tandem mass spectrometry analysis showed that, for most of the strains, the average length of the LPS O-antigen increased. Thus, we have discovered a link between the resistance of bacterial cells to serum and the elongation of the LPS O-antigen. View Full-Text
Keywords: serum resistance; complement; Salmonella; lipopolysaccharide; sialic acid; reptile-associated salmonellosis serum resistance; complement; Salmonella; lipopolysaccharide; sialic acid; reptile-associated salmonellosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pawlak, A.; Rybka, J.; Dudek, B.; Krzyżewska, E.; Rybka, W.; Kędziora, A.; Klausa, E.; Bugla-Płoskońska, G. Salmonella O48 Serum Resistance is Connected with the Elongation of the Lipopolysaccharide O-Antigen Containing Sialic Acid. Int. J. Mol. Sci. 2017, 18, 2022.

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