Metabolic Adaptation in Obesity and Type II Diabetes: Myokines, Adipokines and Hepatokines
AbstractObesity and type II diabetes are characterized by insulin resistance in peripheral tissues. A high caloric intake combined with a sedentary lifestyle is the leading cause of these conditions. Whole-body insulin resistance and its improvement are the result of the combined actions of each insulin-sensitive organ. Among the fundamental molecular mechanisms by which each organ is able to communicate and engage in cross-talk are cytokines or peptides which stem from secretory organs. Recently, it was reported that several cytokines or peptides are secreted from muscle (myokines), adipose tissue (adipokines) and liver (hepatokines) in response to certain nutrition and/or physical activity conditions. Cytokines exert autocrine, paracrine or endocrine effects for the maintenance of energy homeostasis. The present review is focused on the relationship and cross-talk amongst muscle, adipose tissue and the liver as secretory organs in metabolic diseases. View Full-Text
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Oh, K.-J.; Lee, D.S.; Kim, W.K.; Han, B.S.; Lee, S.C.; Bae, K.-H. Metabolic Adaptation in Obesity and Type II Diabetes: Myokines, Adipokines and Hepatokines. Int. J. Mol. Sci. 2017, 18, 8.
Oh K-J, Lee DS, Kim WK, Han BS, Lee SC, Bae K-H. Metabolic Adaptation in Obesity and Type II Diabetes: Myokines, Adipokines and Hepatokines. International Journal of Molecular Sciences. 2017; 18(1):8.Chicago/Turabian Style
Oh, Kyoung-Jin; Lee, Da S.; Kim, Won K.; Han, Baek S.; Lee, Sang C.; Bae, Kwang-Hee. 2017. "Metabolic Adaptation in Obesity and Type II Diabetes: Myokines, Adipokines and Hepatokines." Int. J. Mol. Sci. 18, no. 1: 8.
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