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Int. J. Mol. Sci. 2017, 18(1), 73; doi:10.3390/ijms18010073

Administration of Zinc plus Cyclo-(His-Pro) Increases Hippocampal Neurogenesis in Rats during the Early Phase of Streptozotocin-Induced Diabetes

Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea
Department of Nursing, Inha University, Incheon 22212, Korea
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Reinhard Dallinger
Received: 24 November 2016 / Revised: 22 December 2016 / Accepted: 26 December 2016 / Published: 1 January 2017
(This article belongs to the Special Issue Metal Metabolism in Animals II)
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The effects of zinc supplementation on hippocampal neurogenesis in diabetes mellitus have not been studied. Herein, we investigated the effects of zinc plus cyclo-(His-Pro) (ZC) on neurogenesis occurring in the subgranular zone of dentate gyrus after streptozotocin (STZ)-induced diabetes. ZC (27 mg/kg) was administered by gavage once daily for one or six weeks from the third day after the STZ injection, and histological evaluation was performed at 10 (early phase) or 45 (late phase) days after STZ injection. We found that the proliferation of progenitor cells in STZ-induced diabetic rats showed an increase in the early phase. Additionally, ZC treatment remarkably increased the number of neural progenitor cells (NPCs) and immature neurons in the early phase of STZ-induced diabetic rats. Furthermore, ZC treatment showed increased survival rate of newly generated cells but no difference in the level of neurogenesis in the late phase of STZ-induced diabetic rats. The present study demonstrates that zinc supplementation by ZC increases both NPCs proliferation and neuroblast production at the early phase of diabetes. Thus, this study suggests that zinc supplemented with a histidine/proline complex may have beneficial effects on neurogenesis in patients experiencing the early phase of Type 1 diabetes. View Full-Text
Keywords: zinc; zinc plus cyclo-(His-Pro); neurogenesis; hippocampus; diabetes; streptozotocin zinc; zinc plus cyclo-(His-Pro); neurogenesis; hippocampus; diabetes; streptozotocin

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Choi, B.Y.; Kim, I.Y.; Kim, J.H.; Lee, B.E.; Lee, S.H.; Kho, A.R.; Sohn, M.; Suh, S.W. Administration of Zinc plus Cyclo-(His-Pro) Increases Hippocampal Neurogenesis in Rats during the Early Phase of Streptozotocin-Induced Diabetes. Int. J. Mol. Sci. 2017, 18, 73.

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