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Int. J. Mol. Sci. 2017, 18(4), 820; doi:10.3390/ijms18040820

Anemia in Kawasaki Disease: Hepcidin as a Potential Biomarker

1
Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
2
Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Reinhard Dallinger
Received: 9 March 2017 / Revised: 5 April 2017 / Accepted: 11 April 2017 / Published: 12 April 2017
(This article belongs to the Special Issue Metal Metabolism in Animals II)
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Abstract

Kawasaki disease (KD) is an autoimmune-like disease and acute childhood vasculitis syndrome that affects various systems but has unknown etiology. In addition to the standard diagnostic criteria, anemia is among the most common clinical features of KD patients and is thought to have a more prolonged duration of active inflammation. In 2001, the discovery of a liver-derived peptide hormone known as hepcidin began revolutionizing our understanding of anemia’s relation to a number of inflammatory diseases, including KD. This review focuses on hepcidin-induced iron deficiency’s relation to transient hyposideremia, anemia, and disease outcomes in KD patients, and goes on to suggest possible routes of further study. View Full-Text
Keywords: anemia; hepcidin; Kawasaki disease; iron deficiency anemia; hepcidin; Kawasaki disease; iron deficiency
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Huang, Y.-H.; Kuo, H.-C. Anemia in Kawasaki Disease: Hepcidin as a Potential Biomarker. Int. J. Mol. Sci. 2017, 18, 820.

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