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Int. J. Mol. Sci. 2017, 18(1), 205; doi:10.3390/ijms18010205

Post-Translational Modifications of the TAK1-TAB Complex

Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan
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Academic Editor: Constantinos Stathopoulos
Received: 29 November 2016 / Revised: 12 January 2017 / Accepted: 13 January 2017 / Published: 19 January 2017
(This article belongs to the Special Issue Kinase Signal Transduction)
View Full-Text   |   Download PDF [1475 KB, uploaded 19 January 2017]   |  

Abstract

Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family that is activated by growth factors and cytokines such as TGF-β, IL-1β, and TNF-α, and mediates a wide range of biological processes through activation of the nuclear factor-κB (NF-κB) and the mitogen-activated protein (MAP) kinase signaling pathways. It is well established that activation status of TAK1 is tightly regulated by forming a complex with its binding partners, TAK1-binding proteins (TAB1, TAB2, and TAB3). Interestingly, recent evidence indicates the importance of post-translational modifications (PTMs) of TAK1 and TABs in the regulation of TAK1 activation. To date, a number of PTMs of TAK1 and TABs have been revealed, and these PTMs appear to fine-tune and coordinate TAK1 activities depending on the cellular context. This review therefore focuses on recent advances in the understanding of the PTMs of the TAK1-TAB complex. View Full-Text
Keywords: TAK1; TAB1; TAB2; TAB3; post-translational modification; NF-κB; MAP kinase TAK1; TAB1; TAB2; TAB3; post-translational modification; NF-κB; MAP kinase
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MDPI and ACS Style

Hirata, Y.; Takahashi, M.; Morishita, T.; Noguchi, T.; Matsuzawa, A. Post-Translational Modifications of the TAK1-TAB Complex. Int. J. Mol. Sci. 2017, 18, 205.

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