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Int. J. Mol. Sci. 2017, 18(1), 202; doi:10.3390/ijms18010202

Highly Expression of CD11b and CD32 on Peripheral Blood Mononuclear Cells from Patients with Adult-Onset Still’s Disease

1
Department of Rheumatology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 443-380, Korea
2
Department of Microbiology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 443-380, Korea
3
Department of Biomedical Science, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 443-380, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Charles J. Malemud
Received: 2 December 2016 / Revised: 5 January 2017 / Accepted: 14 January 2017 / Published: 19 January 2017
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
View Full-Text   |   Download PDF [5227 KB, uploaded 19 January 2017]   |  

Abstract

Background: We investigated the potential role of several pattern-recognition receptors (PRRs; CD11b, CD11c, CD32, CD206, CD209, and dectin-1) in adult-onset Still’s disease (AOSD). Methods: The study included 13 untreated AOSD patients, 19 rheumatoid arthritis (RA) patients (as a disease control), and 19 healthy controls (HCs). The PRRs were quantified in peripheral blood using flow cytometry. The serum levels of interleukin-17 (IL-17), IL-18, and IL-23 were measured by enzyme-linked immunosorbent assay. Results: Significantly higher mean frequencies of cells presenting CD11b and CD32 from whole blood were observed in patients with AOSD than in patients with RA or HC. The levels of IL-17, IL-18, and IL-23 were elevated in AOSD patients compared to HCs. CD11b frequencies from whole cells correlated with systemic scores, lactate dehydrogenase (LDH) levels, aspartate transaminase levels, interleukin-23 (IL-23) levels, and IL-18. Frequencies of CD209 from granulocytes were significantly correlated with systemic scores, and the erythrocyte sedimentation rate and levels of C-reactive protein, ferritin, LDH, IL-23, and interleukin-18 (IL-18). Conclusions: Elevated frequencies of circulating CD11b-positive cells and positive correlations with disease activity markers suggest that circulating CD11b-positive cells contribute to the pathogenesis of AOSD. View Full-Text
Keywords: adult-onset still’s disease; pattern recognition receptor; CD11b; CD32; disease activity adult-onset still’s disease; pattern recognition receptor; CD11b; CD32; disease activity
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MDPI and ACS Style

Kim, H.-A.; Choi, B.; Suh, C.-H.; Han, M.H.; Jung, J.-Y.; Sayeed, H.M.; Kim, Y.W.; Sohn, S. Highly Expression of CD11b and CD32 on Peripheral Blood Mononuclear Cells from Patients with Adult-Onset Still’s Disease. Int. J. Mol. Sci. 2017, 18, 202.

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