Highly Expression of CD11b and CD32 on Peripheral Blood Mononuclear Cells from Patients with Adult-Onset Still’s Disease
AbstractBackground: We investigated the potential role of several pattern-recognition receptors (PRRs; CD11b, CD11c, CD32, CD206, CD209, and dectin-1) in adult-onset Still’s disease (AOSD). Methods: The study included 13 untreated AOSD patients, 19 rheumatoid arthritis (RA) patients (as a disease control), and 19 healthy controls (HCs). The PRRs were quantified in peripheral blood using flow cytometry. The serum levels of interleukin-17 (IL-17), IL-18, and IL-23 were measured by enzyme-linked immunosorbent assay. Results: Significantly higher mean frequencies of cells presenting CD11b and CD32 from whole blood were observed in patients with AOSD than in patients with RA or HC. The levels of IL-17, IL-18, and IL-23 were elevated in AOSD patients compared to HCs. CD11b frequencies from whole cells correlated with systemic scores, lactate dehydrogenase (LDH) levels, aspartate transaminase levels, interleukin-23 (IL-23) levels, and IL-18. Frequencies of CD209 from granulocytes were significantly correlated with systemic scores, and the erythrocyte sedimentation rate and levels of C-reactive protein, ferritin, LDH, IL-23, and interleukin-18 (IL-18). Conclusions: Elevated frequencies of circulating CD11b-positive cells and positive correlations with disease activity markers suggest that circulating CD11b-positive cells contribute to the pathogenesis of AOSD. View Full-Text
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Kim, H.-A.; Choi, B.; Suh, C.-H.; Han, M.H.; Jung, J.-Y.; Sayeed, H.M.; Kim, Y.W.; Sohn, S. Highly Expression of CD11b and CD32 on Peripheral Blood Mononuclear Cells from Patients with Adult-Onset Still’s Disease. Int. J. Mol. Sci. 2017, 18, 202.
Kim H-A, Choi B, Suh C-H, Han MH, Jung J-Y, Sayeed HM, Kim YW, Sohn S. Highly Expression of CD11b and CD32 on Peripheral Blood Mononuclear Cells from Patients with Adult-Onset Still’s Disease. International Journal of Molecular Sciences. 2017; 18(1):202.Chicago/Turabian Style
Kim, Hyoun-Ah; Choi, Bunsoon; Suh, Chang-Hee; Han, Mi H.; Jung, Ju-Yang; Sayeed, Hasan M.; Kim, Ye W.; Sohn, Seonghyang. 2017. "Highly Expression of CD11b and CD32 on Peripheral Blood Mononuclear Cells from Patients with Adult-Onset Still’s Disease." Int. J. Mol. Sci. 18, no. 1: 202.
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