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Int. J. Mol. Sci. 2017, 18(1), 158; doi:10.3390/ijms18010158

Reverse Vaccinology: An Approach for Identifying Leptospiral Vaccine Candidates

Núcleo de Biotecnologia, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas RS 96100-000, Brazil
Departamento de Microbiologia e Parasitologia, Instituto de Biologia, Universidade Federal de Pelotas, Pelotas RS 96100-000, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Christopher Woelk
Received: 27 October 2016 / Revised: 5 January 2017 / Accepted: 6 January 2017 / Published: 14 January 2017
(This article belongs to the Special Issue Reverse Vaccinology)
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Leptospirosis is a major public health problem with an incidence of over one million human cases each year. It is a globally distributed, zoonotic disease and is associated with significant economic losses in farm animals. Leptospirosis is caused by pathogenic Leptospira spp. that can infect a wide range of domestic and wild animals. Given the inability to control the cycle of transmission among animals and humans, there is an urgent demand for a new vaccine. Inactivated whole-cell vaccines (bacterins) are routinely used in livestock and domestic animals, however, protection is serovar-restricted and short-term only. To overcome these limitations, efforts have focused on the development of recombinant vaccines, with partial success. Reverse vaccinology (RV) has been successfully applied to many infectious diseases. A growing number of leptospiral genome sequences are now available in public databases, providing an opportunity to search for prospective vaccine antigens using RV. Several promising leptospiral antigens were identified using this approach, although only a few have been characterized and evaluated in animal models. In this review, we summarize the use of RV for leptospirosis and discuss the need for potential improvements for the successful development of a new vaccine towards reducing the burden of human and animal leptospirosis. View Full-Text
Keywords: reverse vaccinology; leptospirosis; Leptospira; genomics; vaccine antigen; bioinformatics; genome mining reverse vaccinology; leptospirosis; Leptospira; genomics; vaccine antigen; bioinformatics; genome mining

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Dellagostin, O.A.; Grassmann, A.A.; Rizzi, C.; Schuch, R.A.; Jorge, S.; Oliveira, T.L.; McBride, A.J.A.; Hartwig, D.D. Reverse Vaccinology: An Approach for Identifying Leptospiral Vaccine Candidates. Int. J. Mol. Sci. 2017, 18, 158.

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