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Int. J. Mol. Sci. 2017, 18(1), 161; doi:10.3390/ijms18010161

Infectious Bursal Disease Virus-Host Interactions: Multifunctional Viral Proteins that Perform Multiple and Differing Jobs

1,2,3
and
1,2,3,*
1
State Key Laboratory of Agrobiotechnology, Beijing 100193, China
2
Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, Beijing 100193, China
3
College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
*
Author to whom correspondence should be addressed.
Academic Editor: Patrick C. Y. Woo
Received: 27 November 2016 / Revised: 24 December 2016 / Accepted: 9 January 2017 / Published: 14 January 2017
(This article belongs to the Special Issue Host-Microbe Interaction)
View Full-Text   |   Download PDF [1469 KB, uploaded 14 January 2017]   |  

Abstract

Infectious bursal disease (IBD) is an acute, highly contagious and immunosuppressive poultry disease caused by IBD virus (IBDV). The consequent immunosuppression increases susceptibility to other infectious diseases and the risk of subsequent vaccination failure as well. Since the genome of IBDV is relatively small, it has a limited number of proteins inhibiting the cellular antiviral responses and acting as destroyers to the host defense system. Thus, these virulence factors must be multifunctional in order to complete the viral replication cycle in a host cell. Insights into the roles of these viral proteins along with their multiple cellular targets in different pathways will give rise to a rational design for safer and effective vaccines. Here we summarize the recent findings that focus on the virus–cell interactions during IBDV infection at the protein level. View Full-Text
Keywords: infectious bursal disease virus (IBDV); immunosuppression; cellular target infectious bursal disease virus (IBDV); immunosuppression; cellular target
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Qin, Y.; Zheng, S.J. Infectious Bursal Disease Virus-Host Interactions: Multifunctional Viral Proteins that Perform Multiple and Differing Jobs. Int. J. Mol. Sci. 2017, 18, 161.

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