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Int. J. Mol. Sci. 2017, 18(1), 147; doi:10.3390/ijms18010147

New Abietane and Kaurane Type Diterpenoids from the Stems of Tripterygium regelii

1
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau 999078, China
2
State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, China
*
Author to whom correspondence should be addressed.
Academic Editor: Jianhua Zhu
Received: 10 December 2016 / Revised: 6 January 2017 / Accepted: 6 January 2017 / Published: 13 January 2017
(This article belongs to the Special Issue Biological Activity of Natural Secondary Metabolite Products)
View Full-Text   |   Download PDF [1228 KB, uploaded 13 January 2017]   |  

Abstract

Eleven new abietane type (111), and one new kaurane (12), diterpenes, together with eleven known compounds (1323), were isolated and identified from the stems of Tripterygium regelii, which has been used as a traditional folk Chinese medicine for the treatment of rheumatoid arthritis in China. The structures of new compounds were characterized by means of the interpretation of high-resolution electrospray ionization mass spectrometry (HRESIMS), extensive nuclear magnetic resonance (NMR) spectroscopic data and comparisons of their experimental CD spectra with calculated electronic circular dichroism (ECD) spectra. Compound 1 is the first abietane type diterpene with an 18→1 lactone ring. Compound 19 was isolated from the plants of the Tripterygium genus for the first time, and compounds 1417 were isolated from T. regelii for the first time. Triregelin I (9) showed significant cytotoxicity against A2780 and HepG2 with IC50 values of 5.88 and 11.74 µM, respectively. It was found that this compound was inactive against MCF-7 cells. The discovery of these twelve new diterpenes not only provided information on chemical substances of T. regelii, but also contributed to the chemical diversity of natural terpenoids. View Full-Text
Keywords: Tripterygium regelii; diterpenoids; cytotoxicity Tripterygium regelii; diterpenoids; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Fan, D.; Zhou, S.; Zheng, Z.; Zhu, G.-Y.; Yao, X.; Yang, M.-R.; Jiang, Z.-H.; Bai, L.-P. New Abietane and Kaurane Type Diterpenoids from the Stems of Tripterygium regelii. Int. J. Mol. Sci. 2017, 18, 147.

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