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Int. J. Mol. Sci. 2017, 18(1), 120; doi:10.3390/ijms18010120

The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles

Department of Stem Cell & Regenerative Biotechnology, Incurable Disease Animal Model and Stem Cell Institute (IDASI), Konkuk University, Gwangjin-gu, Seoul 05029, Korea
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Academic Editor: Bing Yan
Received: 25 November 2016 / Revised: 27 December 2016 / Accepted: 4 January 2017 / Published: 10 January 2017
(This article belongs to the Collection Bioactive Nanoparticles)
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Abstract

Nanoparticles (NPs) possess unique physical and chemical properties that make them appropriate for various applications. The structural alteration of metallic NPs leads to different biological functions, specifically resulting in different potentials for the generation of reactive oxygen species (ROS). The amount of ROS produced by metallic NPs correlates with particle size, shape, surface area, and chemistry. ROS possess multiple functions in cellular biology, with ROS generation a key factor in metallic NP-induced toxicity, as well as modulation of cellular signaling involved in cell death, proliferation, and differentiation. In this review, we briefly explained NP classes and their biomedical applications and describe the sources and roles of ROS in NP-related biological functions in vitro and in vivo. Furthermore, we also described the roles of metal NP-induced ROS generation in stem cell biology. Although the roles of ROS in metallic NP-related biological functions requires further investigation, modulation and characterization of metallic NP-induced ROS production are promising in the application of metallic NPs in the areas of regenerative medicine and medical devices. View Full-Text
Keywords: nanoparticles (NPs); reactive oxygen species (ROS); stem cells; toxicity; cellular signaling; regenerative medicine nanoparticles (NPs); reactive oxygen species (ROS); stem cells; toxicity; cellular signaling; regenerative medicine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Abdal Dayem, A.; Hossain, M.K.; Lee, S.B.; Kim, K.; Saha, S.K.; Yang, G.-M.; Choi, H.Y.; Cho, S.-G. The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles. Int. J. Mol. Sci. 2017, 18, 120.

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