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Int. J. Mol. Sci. 2016, 17(9), 1483; doi:10.3390/ijms17091483

Mammalian Metallothionein-2A and Oxidative Stress

Department of Cardiovascular Institute, Affiliated Hospital of Hainan Medical College, Haikou 570102, China
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Authors to whom correspondence should be addressed.
Academic Editors: Masatoshi Maki and Charles J. Malemud
Received: 21 May 2016 / Revised: 19 August 2016 / Accepted: 24 August 2016 / Published: 6 September 2016
(This article belongs to the Special Issue Metalloproteins)
View Full-Text   |   Download PDF [2867 KB, uploaded 6 September 2016]   |  

Abstract

Mammalian metallothionein-2A (MT2A) has received considerable attention in recent years due to its crucial pathophysiological role in anti-oxidant, anti-apoptosis, detoxification and anti-inflammation. For many years, most studies evaluating the effects of MT2A have focused on reactive oxygen species (ROS), as second messengers that lead to oxidative stress injury of cells and tissues. Recent studies have highlighted that oxidative stress could activate mitogen-activated protein kinases (MAPKs), and MT2A, as a mediator of MAPKs, to regulate the pathogenesis of various diseases. However, the molecule mechanism of MT2A remains elusive. A deeper understanding of the functional, biochemical and molecular characteristics of MT2A would be identified, in order to bring new opportunities for oxidative stress therapy. View Full-Text
Keywords: metallothionein-2A; oxidative stress; mitogen-activated protein kinases; reactive oxygen species metallothionein-2A; oxidative stress; mitogen-activated protein kinases; reactive oxygen species
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Ling, X.-B.; Wei, H.-W.; Wang, J.; Kong, Y.-Q.; Wu, Y.-Y.; Guo, J.-L.; Li, T.-F.; Li, J.-K. Mammalian Metallothionein-2A and Oxidative Stress. Int. J. Mol. Sci. 2016, 17, 1483.

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