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Int. J. Mol. Sci. 2016, 17(9), 1479; doi:10.3390/ijms17091479

Roles of Voltage-Gated Tetrodotoxin-Sensitive Sodium Channels NaV1.3 and NaV1.7 in Diabetes and Painful Diabetic Neuropathy

Department of Endocrinology, The General Hospital of the PLA Rocket Force, Beijing 100088, China
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Author to whom correspondence should be addressed.
Academic Editor: Zhiguo Zhang
Received: 6 May 2016 / Revised: 24 August 2016 / Accepted: 25 August 2016 / Published: 5 September 2016
(This article belongs to the Special Issue Diabetic Complications: Pathophysiology, Mechanisms, and Therapies)
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Abstract

Diabetes mellitus (DM) is a common chronic medical problem worldwide; one of its complications is painful peripheral neuropathy, which can substantially erode quality of life and increase the cost of management. Despite its clinical importance, the pathogenesis of painful diabetic neuropathy (PDN) is complex and incompletely understood. Voltage-gated sodium channels (VGSCs) link many physiological processes to electrical activity by controlling action potentials in all types of excitable cells. Two isoforms of VGSCs, NaV1.3 and NaV1.7, which are encoded by the sodium voltage-gated channel alpha subunit 3 and 9 (Scn3A and Scn9A) genes, respectively, have been identified in both peripheral nociceptive neurons of dorsal root ganglion (DRG) and pancreatic islet cells. Recent advances in our understanding of tetrodotoxin-sensitive (TTX-S) sodium channels NaV1.3 and NaV1.7 lead to the rational doubt about the cause–effect relation between diabetes and painful neuropathy. In this review, we summarize the roles of NaV1.3 and NaV1.7 in islet cells and DRG neurons, discuss the link between DM and painful neuropathy, and present a model, which may provide a starting point for further studies aimed at identifying the mechanisms underlying diabetes and painful neuropathy. View Full-Text
Keywords: diabetes mellitus; painful diabetic neuropathy; NaV1.3; NaV1.7; dorsal root ganglion neurons; pancreatic islet cells diabetes mellitus; painful diabetic neuropathy; NaV1.3; NaV1.7; dorsal root ganglion neurons; pancreatic islet cells
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MDPI and ACS Style

Yang, L.; Li, Q.; Liu, X.; Liu, S. Roles of Voltage-Gated Tetrodotoxin-Sensitive Sodium Channels NaV1.3 and NaV1.7 in Diabetes and Painful Diabetic Neuropathy. Int. J. Mol. Sci. 2016, 17, 1479.

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