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Int. J. Mol. Sci. 2016, 17(9), 1478; doi:10.3390/ijms17091478

Pereskia aculeata Muller (Cactaceae) Leaves: Chemical Composition and Biological Activities

1
Department of Pharmacy, University of Salerno, 84084 Fisciano (Salerno), Italy
2
Department of Agronomy, University of Rio Grande do Sul (UFRGS), 91501-970 Porto Alegre, Brazil
3
Istituto di Scienze dell’Alimentazione, Consiglio Nazionale delle Ricerche (ISA-CNR), 83100 Avellino, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 22 July 2016 / Revised: 23 August 2016 / Accepted: 23 August 2016 / Published: 3 September 2016
(This article belongs to the Section Bioactives and Nutraceuticals)
View Full-Text   |   Download PDF [1696 KB, uploaded 3 September 2016]   |  

Abstract

The aims of this work were to study the chemical composition of the essential oil from the leaves of Pereskia aculeata and to evaluate some biological activities of three leaf extracts. The phenolic content, antioxidant activity, and in vitro antimicrobial and antifungal activities were determined. The methanol extract showed antioxidant activity (EC50 7.09 mg/mL) and high polyphenols content (15.04 ± 0.31 mg gallic acid equivalents (GAE)/g). The petroleum ether extract exhibited potent antibacterial activity against Escherichia coli, whereas the chloroform extract showed inhibitory activity against Bacillus cereus and Staphylococcus aureus. The petroleum ether and methanol extracts were more effective in inhibiting the growth of Aspergillus versicolor. The possible cytotoxicity of extracts on neuroblastoma SH-SY5Y cancer cell line and the influence on adenylate cyclase (ADCY) expression was also studied. P. aculeata chloroform extract showed antiproliferative activity with an IC50 value of 262.83 µg/mL. Treatments of SH-SY5Y neuroblastoma cells with 100 µg/mL of methanol extract significantly reduced ADCY1 expression. View Full-Text
Keywords: Pereskia aculeata; essential oil; leaf extracts; antioxidant activity; antibacterial activity; antifungal activity; cytotoxicity; adenylate cyclase (ADCY) Pereskia aculeata; essential oil; leaf extracts; antioxidant activity; antibacterial activity; antifungal activity; cytotoxicity; adenylate cyclase (ADCY)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Souza, L.F.; Caputo, L.; Inchausti De Barros, I.B.; Fratianni, F.; Nazzaro, F.; De Feo, V. Pereskia aculeata Muller (Cactaceae) Leaves: Chemical Composition and Biological Activities. Int. J. Mol. Sci. 2016, 17, 1478.

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