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Int. J. Mol. Sci. 2016, 17(9), 1448; doi:10.3390/ijms17091448

Novel Anti-Melanogenesis Properties of Polydeoxyribonucleotide, a Popular Wound Healing Booster

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea
Department of Dermatology, College of medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul 07441, Korea
MJ All Skin Clinic, Seoul 04537, Korea
YeMiWon Clinic, Seoul 06280, Korea
Author to whom correspondence should be addressed.
Academic Editor: Manickam Sugumaran
Received: 20 June 2016 / Revised: 20 August 2016 / Accepted: 25 August 2016 / Published: 1 September 2016
(This article belongs to the Special Issue Biochemistry and Mechanisms of Melanogenesis)
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Polydeoxyribonucleotide (PDRN), a deoxyribonucleotide polymer, is popularly used for faster healing of cutaneous wounds and boosting of neocollagenesis of photoaged skin among current dermatologic practitioners. Some patients receiving PDRN injection treatment also reported improvement of photoaging-associated mottled pigmentation (PMP). To investigate the effect of PDRN on cutaneous melanogenesis, we examined the effect of PDRN and an available product (Placentex®) containing PDRN on melanogenesis using human melanocytes-keratinocytes cocultures and mouse melanocytes. Melanin content, tyrosinase activity, and levels of microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related protein (TRP-1) were determined. Intracellular signaling pathways were assessed by Western blotting. PDRN and Placentex® led to decreases in melanin content, tyrosinase activity, and MITF and TRP-1 expression with concomitant increases in phosphorylated forms of extracellular signal-regulated protein kinase (ERK) and AKT in mouse melanocytes. More importantly, both PDRN and Placentex® significantly suppressed the melanin content in human melanocyte–keratinocyte cocultures. Clinical evaluation of six female patients with facial hyperpigmentation after three sessions of intradermal PDRN injections using a 5-point scale revealed that PDRN led to more than noticeable improvements in hyperpigmented lesions. This is the first study to demonstrate that PDRN, which is known for its wound-healing properties, may have novel anti-melanogenesis and potential skin whitening properties. View Full-Text
Keywords: polydeoxyribonucleotide; melanogenesis; coculture; hyperpigmentation polydeoxyribonucleotide; melanogenesis; coculture; hyperpigmentation

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Noh, T.K.; Chung, B.Y.; Kim, S.Y.; Lee, M.H.; Kim, M.J.; Youn, C.S.; Lee, M.W.; Chang, S.E. Novel Anti-Melanogenesis Properties of Polydeoxyribonucleotide, a Popular Wound Healing Booster. Int. J. Mol. Sci. 2016, 17, 1448.

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