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Int. J. Mol. Sci. 2016, 17(9), 1455; doi:10.3390/ijms17091455

Exogenous Ghrelin Accelerates the Healing of Acetic Acid-Induced Colitis in Rats

1
Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegórzecka St., 31-531 Cracow, Poland
2
Department of Anatomy, Faculty of Medicine, Jagiellonian University Medical College, 31-034 Cracow, Poland
3
Department of Pediatrics, Gastroenterology and Nutrition, University Children’s Hospital, Faculty of Medicine, Jagiellonian University Medical College, 30-663 Cracow, Poland
4
Department of Pathomorphology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Cracow, Poland
5
Department of Medical Physiology Faculty of Health Sciences, Jagiellonian University Medical College, 31-126 Cracow, Poland
6
Department of Cardiovascular Surgery and Transplantology, Jagiellonian University, JP II Hospital, 31-202 Cracow, Poland
7
Department of Pathophysiology, Faculty of Medicine, Jagiellonian University Medical College, 31-121 Cracow, Poland
8
Department of Pharmacology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Cracow, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Suzanne L. Dickson
Received: 31 May 2016 / Revised: 18 August 2016 / Accepted: 26 August 2016 / Published: 1 September 2016
(This article belongs to the Special Issue Neurobiological Perspectives on Ghrelin)
View Full-Text   |   Download PDF [1409 KB, uploaded 1 September 2016]   |  

Abstract

Previous studies have shown that ghrelin reduces colonic inflammation induced by trinitrobenzene sulfonic acid and dextran sodium sulfate. In the present study we determined the effect of treatment with ghrelin on the course of acetic acid-induced colitis in rats. Rectal administration of 3% acetic acid solution led to induction of colitis in all animals. Damage of the colonic wall was accompanied by an increase in mucosal concentration of pro-inflammatory interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), as well mucosal activity of myeloperoxidase. Moreover, induction of colitis led to a reduction in colonic blood flow and DNA synthesis. Administration of ghrelin after induction of colitis led to faster regeneration of the colonic wall and reduction in colonic levels of IL-1β, TNF-α, and myeloperoxidase. In addition, treatment with ghrelin improved mucosal DNA synthesis and blood flow. Our study disclosed that ghrelin exhibits a strong anti-inflammatory and healing effect in acetic acid-induced colitis. Our current observation in association with previous findings that ghrelin exhibits curative effect in trinitrobenzene sulfonic acid- and dextran sodium sulfate-induced colitis suggest that therapeutic effect of ghrelin in the colon is universal and independent of the primary cause of colitis. View Full-Text
Keywords: colitis; DNA synthesis; mucosal blood flow; myeloperoxidase; interleukin-1β colitis; DNA synthesis; mucosal blood flow; myeloperoxidase; interleukin-1β
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Matuszyk, A.; Ceranowicz, P.; Warzecha, Z.; Cieszkowski, J.; Ceranowicz, D.; Gałązka, K.; Bonior, J.; Jaworek, J.; Bartuś, K.; Gil, K.; Olszanecki, R.; Dembiński, A. Exogenous Ghrelin Accelerates the Healing of Acetic Acid-Induced Colitis in Rats. Int. J. Mol. Sci. 2016, 17, 1455.

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