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Int. J. Mol. Sci. 2016, 17(7), 1176; doi:10.3390/ijms17071176

Protective Effect of Salicornia europaea Extracts on High Salt Intake-Induced Vascular Dysfunction and Hypertension

1
College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Muan-gun, Jeonnam 58554, Korea
2
UMR CNRS 7213, Laboratoire de Biophotonique et Pharmacologie, Faculté de Pharmacie, Université de Strasbourg, Illkirch 67401, France
3
Research Center, Phyto Corporation, Seoul 08826, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Chang Won Choi
Received: 19 May 2016 / Revised: 8 July 2016 / Accepted: 14 July 2016 / Published: 21 July 2016
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

High salt intake causes and aggravates arterial hypertension and vascular dysfunction. We investigated the effect of Salicornia europaea extracts (SE) on vascular function and blood pressure. SE constituents were analyzed using high performance liquid chromatography, and SE’s effect on vascular function was evaluated in isolated porcine coronary arteries. SE’s vascular protective effect was also evaluated in vivo using normotensive and spontaneous hypertensive rats (SHRs). SE mainly contained sodium chloride (55.6%), 5-(hydroxymethyl)furfural, p-coumaric acid, and trans-ferulic acid. High sodium (160 mmol/L) induced vascular dysfunction; however, SE containing the same quantity of sodium did not cause vascular dysfunction. Among the compounds in SE, trans-ferulic acid accounts for the vascular protective effect. Normotensive rats fed a high-salt diet showed significantly increased systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), which decreased significantly in the SE-treated groups. In SHRs, high edible salt intake significantly increased SBP, DBP, and MAP, but SE intake was associated with a significantly lower MAP. Thus, SE did not induce vascular dysfunction, and trans-ferulic acid might be at least partly responsible for the vasoprotective effect of SE. Taken together, SE could be used as an alternative to purified salt to prevent and ameliorate hypertension. View Full-Text
Keywords: Salicornia europaea; vascular dysfunction; blood pressure; hypertension Salicornia europaea; vascular dysfunction; blood pressure; hypertension
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Panth, N.; Park, S.-H.; Kim, H.J.; Kim, D.-H.; Oak, M.-H. Protective Effect of Salicornia europaea Extracts on High Salt Intake-Induced Vascular Dysfunction and Hypertension. Int. J. Mol. Sci. 2016, 17, 1176.

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