Inflammaging and Frailty Status Do Not Result in an Increased Extracellular Vesicle Concentration in Circulation
AbstractIn the last decades extracellular vesicles (EVs) have emerged as key players for intercellular communication. In the case of inflammation, several studies have reported that EV levels are increased in circulation during inflammatory episodes. Based on this, we investigated whether aging results in elevated EV number, as a basal proinflammatory status termed “inflammaging” has been described in aged individuals. Moreover, we also hypothesized that frailty and dependence conditions of the elderly could affect EV concentration in plasma. Results showed that inflammaging, frailty or dependence status do not result in EV increase, at least in the total number of EVs in circulation. These results open a new perspective for investigating the role of EVs in human aging and in the inflammaging process. View Full-Text
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Alberro, A.; Sáenz-Cuesta, M.; Muñoz-Culla, M.; Mateo-Abad, M.; Gonzalez, E.; Carrasco-Garcia, E.; Araúzo-Bravo, M.J.; Matheu, A.; Vergara, I.; Otaegui, D. Inflammaging and Frailty Status Do Not Result in an Increased Extracellular Vesicle Concentration in Circulation. Int. J. Mol. Sci. 2016, 17, 1168.
Alberro A, Sáenz-Cuesta M, Muñoz-Culla M, Mateo-Abad M, Gonzalez E, Carrasco-Garcia E, Araúzo-Bravo MJ, Matheu A, Vergara I, Otaegui D. Inflammaging and Frailty Status Do Not Result in an Increased Extracellular Vesicle Concentration in Circulation. International Journal of Molecular Sciences. 2016; 17(7):1168.Chicago/Turabian Style
Alberro, Ainhoa; Sáenz-Cuesta, Matías; Muñoz-Culla, Maider; Mateo-Abad, Maider; Gonzalez, Esperanza; Carrasco-Garcia, Estefania; Araúzo-Bravo, Marcos J.; Matheu, Ander; Vergara, Itziar; Otaegui, David. 2016. "Inflammaging and Frailty Status Do Not Result in an Increased Extracellular Vesicle Concentration in Circulation." Int. J. Mol. Sci. 17, no. 7: 1168.
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