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Open AccessCommunication
Int. J. Mol. Sci. 2016, 17(7), 1168; doi:10.3390/ijms17071168

Inflammaging and Frailty Status Do Not Result in an Increased Extracellular Vesicle Concentration in Circulation

1
Multiple Sclerosis Unit, Biodonostia Health Research Institute—Donostia University Hospital, San Sebastian 20014, Spain
2
Spanish Network of Multiple Sclerosis, Barcelona 08028, Spain
3
Primary Care Research Unit-Gipuzkoa, Osakidetza, Biodonostia Health Research Institute, San Sebastian 20014, Spain
4
Metabolomics Unit, CIC bioGUNE, CIBERehd, Technology Park of Bizkaia, Derio, Bizkaia 48980, Spain
5
Cellular Oncology Group, Biodonostia Health Research Institute, San Sebastian 20014, Spain
6
Computational Biology and Systems Biomedicine Group, Biodonostia Health Research Institute, San Sebastian 20014, Spain
7
IKERBASQUE, Basque Foundation for Science, Bilbao 48015, Spain
8
Health Services Research on Chronic Patients Network (REDISSEC), Bilbao 48013, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Gregor Drummen
Received: 16 May 2016 / Revised: 4 July 2016 / Accepted: 13 July 2016 / Published: 20 July 2016
(This article belongs to the Special Issue Focus on Extracellular Vesicles)
View Full-Text   |   Download PDF [959 KB, uploaded 20 July 2016]   |  

Abstract

In the last decades extracellular vesicles (EVs) have emerged as key players for intercellular communication. In the case of inflammation, several studies have reported that EV levels are increased in circulation during inflammatory episodes. Based on this, we investigated whether aging results in elevated EV number, as a basal proinflammatory status termed “inflammaging” has been described in aged individuals. Moreover, we also hypothesized that frailty and dependence conditions of the elderly could affect EV concentration in plasma. Results showed that inflammaging, frailty or dependence status do not result in EV increase, at least in the total number of EVs in circulation. These results open a new perspective for investigating the role of EVs in human aging and in the inflammaging process. View Full-Text
Keywords: extracellular vesicle; intercellular communication; human aging; inflammaging; frailty; interleukin-6 extracellular vesicle; intercellular communication; human aging; inflammaging; frailty; interleukin-6
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Alberro, A.; Sáenz-Cuesta, M.; Muñoz-Culla, M.; Mateo-Abad, M.; Gonzalez, E.; Carrasco-Garcia, E.; Araúzo-Bravo, M.J.; Matheu, A.; Vergara, I.; Otaegui, D. Inflammaging and Frailty Status Do Not Result in an Increased Extracellular Vesicle Concentration in Circulation. Int. J. Mol. Sci. 2016, 17, 1168.

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