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Int. J. Mol. Sci. 2016, 17(7), 1116; doi:10.3390/ijms17071116

Cytoskeletal Regulation of Inflammation and Its Impact on Skin Blistering Disease Epidermolysis Bullosa Acquisita

1
Future Industries Institute, Regenerative Medicine, University of South Australia, Mawson Lakes 5095, Adelaide, Australia
2
Institute of Experimental Dermatology, University of Lubeck, Lubeck 23562, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Chris Jackson
Received: 16 May 2016 / Revised: 30 June 2016 / Accepted: 7 July 2016 / Published: 13 July 2016
(This article belongs to the Special Issue Inflammatory Skin Conditions)
View Full-Text   |   Download PDF [5061 KB, uploaded 13 July 2016]   |  

Abstract

Actin remodelling proteins regulate cytoskeletal cell responses and are important in both innate and adaptive immunity. These responses play a major role in providing a fine balance in a cascade of biological events that results in either protective acute inflammation or chronic inflammation that leads to a host of diseases including autoimmune inflammation mediated epidermolysis bullosa acquisita (EBA). This review describes the role of the actin cytoskeleton and in particular the actin remodelling protein called Flightless I (Flii) in regulating cellular inflammatory responses and its subsequent effect on the autoimmune skin blistering disease EBA. It also outlines the potential of an antibody based therapy for decreasing Flii expression in vivo to ameliorate the symptoms associated with EBA. View Full-Text
Keywords: actin cytoskeleton; inflammation; skin blistering; epidermolysis bullosa acquisita actin cytoskeleton; inflammation; skin blistering; epidermolysis bullosa acquisita
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MDPI and ACS Style

Kopecki, Z.; Ludwig, R.J.; Cowin, A.J. Cytoskeletal Regulation of Inflammation and Its Impact on Skin Blistering Disease Epidermolysis Bullosa Acquisita. Int. J. Mol. Sci. 2016, 17, 1116.

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