Next Article in Journal
Piriformospora indica Stimulates Root Metabolism of Arabidopsis thaliana
Next Article in Special Issue
Protective Effect of Pretreatment with Acenocoumarol in Cerulein-Induced Acute Pancreatitis
Previous Article in Journal
miR-494-3p Induces Cellular Senescence and Enhances Radiosensitivity in Human Oral Squamous Carcinoma Cells
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2016, 17(7), 1090; doi:10.3390/ijms17071090

The Prognostic and Predictive Role of Epidermal Growth Factor Receptor in Surgical Resected Pancreatic Cancer

1,2,3,†
,
1,2,3,†,* , 1,2,3,†
,
1,2,3
,
1,2,3
,
1,2,3
,
1,2,3
,
1,2,3
,
1,2,3
,
1,2,3
,
3,4
,
1,2,3
and
1,2,3,*
1
Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China
2
Department of Pancreas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China
3
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
4
Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editors: Srikumar Chellappan and Jaya Padmanabhan
Received: 18 May 2016 / Revised: 28 June 2016 / Accepted: 1 July 2016 / Published: 8 July 2016
(This article belongs to the Special Issue Pancreatic Disorders)
View Full-Text   |   Download PDF [1970 KB, uploaded 19 July 2016]   |  

Abstract

The data regarding the prognostic significance of EGFR (epidermal growth factor receptor) expression and adjuvant therapy in patients with resected pancreatic cancer are insufficient. We retrospectively investigated EGFR status in 357 resected PDAC (pancreatic duct adenocarcinoma) patients using tissue immunohistochemistry and validated the possible role of EGFR expression in predicting prognosis. The analysis was based on excluding the multiple confounding parameters. A negative association was found between overall EGFR status and postoperative survival (p = 0.986). Remarkably, adjuvant chemotherapy and radiotherapy were significantly associated with favorable postoperative survival, which prolonged median overall survival (OS) for 5.8 and 10.2 months (p = 0.009 and p = 0.006, respectively). Kaplan–Meier analysis showed that adjuvant chemotherapy correlated with an obvious survival benefit in the EGFR-positive subgroup rather than in the EGFR-negative subgroup. In the subgroup analyses, chemotherapy was highly associated with increased postoperative survival in the EGFR-positive subgroup (p = 0.002), and radiotherapy had a significant survival benefit in the EGFR-negative subgroup (p = 0.029). This study demonstrated that EGFR expression is not correlated with outcome in resected pancreatic cancer patients. Adjuvant chemotherapy and radiotherapy were significantly associated with improved survival in contrary EGFR expressing subgroup. Further studies of EGFR as a potential target for pancreatic cancer treatment are warranted. View Full-Text
Keywords: pancreatic ductal adenocarcinoma; EGFR status; overall survival; adjuvant therapy; prognosis pancreatic ductal adenocarcinoma; EGFR status; overall survival; adjuvant therapy; prognosis
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Guo, M.; Luo, G.; Liu, C.; Cheng, H.; Lu, Y.; Jin, K.; Liu, Z.; Long, J.; Liu, L.; Xu, J.; Huang, D.; Ni, Q.; Yu, X. The Prognostic and Predictive Role of Epidermal Growth Factor Receptor in Surgical Resected Pancreatic Cancer. Int. J. Mol. Sci. 2016, 17, 1090.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top