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Int. J. Mol. Sci. 2016, 17(10), 1709; doi:10.3390/ijms17101709

Protective Effect of Pretreatment with Acenocoumarol in Cerulein-Induced Acute Pancreatitis

1
Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegórzecka St., 31-531 Cracow, Poland
2
Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Cracow, Poland
3
The Second Department of General Surgery, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Cracow, Poland
4
Department of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Cracow, Poland
5
Department of Pharmacology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Cracow, Poland
6
Department of Pathology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Cracow, Poland
7
Faculty of Physical Education and Sport, University of Physical Education, 31-571 Cracow, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Srikumar Chellappan
Received: 14 August 2016 / Revised: 12 September 2016 / Accepted: 30 September 2016 / Published: 12 October 2016
(This article belongs to the Special Issue Pancreatic Disorders)
View Full-Text   |   Download PDF [2763 KB, uploaded 12 October 2016]   |  

Abstract

Coagulation is recognized as a key player in inflammatory and autoimmune diseases. The aim of the current research was to examine the effect of pretreatment with acenocoumarol on the development of acute pancreatitis (AP) evoked by cerulein. Methods: AP was induced in rats by cerulein administered intraperitoneally. Acenocoumarol (50, 100 or 150 µg/kg/dose/day) or saline were given once daily for seven days before AP induction. Results: In rats with AP, pretreatment with acenocoumarol administered at the dose of 50 or 100 µg/kg/dose/day improved pancreatic histology, reducing the degree of edema and inflammatory infiltration, and vacuolization of acinar cells. Moreover, pretreatment with acenocoumarol given at the dose of 50 or 100 µg/kg/dose/day reduced the AP-evoked increase in pancreatic weight, serum activity of amylase and lipase, and serum concentration of pro-inflammatory interleukin-1β, as well as ameliorated pancreatic DNA synthesis and pancreatic blood flow. In contrast, acenocoumarol given at the dose of 150 μg/kg/dose did not exhibit any protective effect against cerulein-induced pancreatitis. Conclusion: Low doses of acenocoumarol, given before induction of AP by cerulein, inhibit the development of that inflammation. View Full-Text
Keywords: acute pancreatitis; coagulation; inflammation; interleukin-1β; lipase acute pancreatitis; coagulation; inflammation; interleukin-1β; lipase
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Warzecha, Z.; Sendur, P.; Ceranowicz, P.; Dembiński, M.; Cieszkowski, J.; Kuśnierz-Cabala, B.; Olszanecki, R.; Tomaszewska, R.; Ambroży, T.; Dembiński, A. Protective Effect of Pretreatment with Acenocoumarol in Cerulein-Induced Acute Pancreatitis. Int. J. Mol. Sci. 2016, 17, 1709.

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