Site-Specific Genome Engineering in Human Pluripotent Stem Cells
AbstractThe possibility to generate patient-specific induced pluripotent stem cells (iPSCs) offers an unprecedented potential of applications in clinical therapy and medical research. Human iPSCs and their differentiated derivatives are tools for diseases modelling, drug discovery, safety pharmacology, and toxicology. Moreover, they allow for the engineering of bioartificial tissue and are promising candidates for cellular therapies. For many of these applications, the ability to genetically modify pluripotent stem cells (PSCs) is indispensable, but efficient site-specific and safe technologies for genetic engineering of PSCs were developed only recently. By now, customized engineered nucleases provide excellent tools for targeted genome editing, opening new perspectives for biomedical research and cellular therapies. View Full-Text
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Merkert, S.; Martin, U. Site-Specific Genome Engineering in Human Pluripotent Stem Cells. Int. J. Mol. Sci. 2016, 17, 1000.
Merkert S, Martin U. Site-Specific Genome Engineering in Human Pluripotent Stem Cells. International Journal of Molecular Sciences. 2016; 17(7):1000.Chicago/Turabian Style
Merkert, Sylvia; Martin, Ulrich. 2016. "Site-Specific Genome Engineering in Human Pluripotent Stem Cells." Int. J. Mol. Sci. 17, no. 7: 1000.