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Int. J. Mol. Sci. 2016, 17(6), 985; doi:10.3390/ijms17060985

RNA Secondary Structure Modulates FMRP’s Bi-Functional Role in the MicroRNA Pathway

1
Cell and Developmental Biology, University of Illinois-Urbana Champaign, Urbana, IL 61801, USA
2
College of Medicine, University of Illinois-Urbana Champaign, Urbana, IL 61801, USA
3
Neuroscience Program, University of Illinois-Urbana Champaign, B107 Chemical Life Sciences Laboratory, Urbana, IL 61801, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Y-h. Taguchi
Received: 17 March 2016 / Revised: 23 May 2016 / Accepted: 14 June 2016 / Published: 22 June 2016
(This article belongs to the Special Issue MicroRNA Regulation)
View Full-Text   |   Download PDF [1602 KB, uploaded 22 June 2016]   |  

Abstract

MicroRNAs act by post-transcriptionally regulating the gene expression of 30%–60% of mammalian genomes. MicroRNAs are key regulators in all cellular processes, though the mechanism by which the cell activates or represses microRNA-mediated translational regulation is poorly understood. In this review, we discuss the RNA binding protein Fragile X Mental Retardation Protein (FMRP) and its role in microRNA-mediated translational regulation. Historically, FMRP is known to function as a translational suppressor. However, emerging data suggests that FMRP has both an agonistic and antagonistic role in regulating microRNA-mediated translational suppression. This bi-functional role is dependent on FMRP’s interaction with the RNA helicase Moloney leukemia virus 10 (MOV10), which modifies the structural landscape of bound mRNA, therefore facilitating or inhibiting its association with the RNA-Induced Silencing Complex. View Full-Text
Keywords: FMRP; G-Quadruplex; microRNA; MOV10; RNA binding proteins; secondary structure FMRP; G-Quadruplex; microRNA; MOV10; RNA binding proteins; secondary structure
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Kenny, P.; Ceman, S. RNA Secondary Structure Modulates FMRP’s Bi-Functional Role in the MicroRNA Pathway. Int. J. Mol. Sci. 2016, 17, 985.

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