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Int. J. Mol. Sci. 2016, 17(6), 948; doi:10.3390/ijms17060948

The Effect of MCP-1/CCR2 on the Proliferation and Senescence of Epidermal Constituent Cells in Solar Lentigo

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Korea
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editors: Andrzej T. Slominski and Sanjay K. Srivastava
Received: 1 April 2016 / Revised: 7 June 2016 / Accepted: 8 June 2016 / Published: 15 June 2016
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Solar lentigo (SL) is a representative photoaging skin disorder. Alteration of the main epidermal constituent cells—keratinocytes and melanocytes—in relation to the photoaged dermal environment or chemokine/cytokine network is suggested as its pathogenesis. Among these, we focused on monocyte chemoattractant protein-1 (MCP-1), as it is known to be associated with tissue aging. For the first time, we report that the MCP-1 receptor, CCR2, is expressed in normal human melanocytes. In SL tissue, there was an increase of CCR2+Melan A+ melanocytes with positivity to Rb protein compared to peri-lesional normal skin. MCP-1 induced the proliferation of normal human melanocytes without a significant change in the melanin content. MCP-1 treatment in normal human keratinocytes showed an increase in senescence-associated β-galactosidase staining and p53 and p21 protein expressions. In summary, MCP-1 may participate in the development of SL by affecting epidermal constituent cells, for example, by inducing melanocyte proliferation and keratinocyte senescence. View Full-Text
Keywords: solar lentigo; monocyte chemoattractant protein-1; epidermal constituent cells solar lentigo; monocyte chemoattractant protein-1; epidermal constituent cells

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Lee, W.J.; Jo, S.Y.; Lee, M.H.; Won, C.H.; Lee, M.W.; Choi, J.H.; Chang, S.E. The Effect of MCP-1/CCR2 on the Proliferation and Senescence of Epidermal Constituent Cells in Solar Lentigo. Int. J. Mol. Sci. 2016, 17, 948.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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