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Int. J. Mol. Sci. 2016, 17(6), 948; doi:10.3390/ijms17060948

The Effect of MCP-1/CCR2 on the Proliferation and Senescence of Epidermal Constituent Cells in Solar Lentigo

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Korea
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editors: Andrzej T. Slominski and Sanjay K. Srivastava
Received: 1 April 2016 / Revised: 7 June 2016 / Accepted: 8 June 2016 / Published: 15 June 2016
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Solar lentigo (SL) is a representative photoaging skin disorder. Alteration of the main epidermal constituent cells—keratinocytes and melanocytes—in relation to the photoaged dermal environment or chemokine/cytokine network is suggested as its pathogenesis. Among these, we focused on monocyte chemoattractant protein-1 (MCP-1), as it is known to be associated with tissue aging. For the first time, we report that the MCP-1 receptor, CCR2, is expressed in normal human melanocytes. In SL tissue, there was an increase of CCR2+Melan A+ melanocytes with positivity to Rb protein compared to peri-lesional normal skin. MCP-1 induced the proliferation of normal human melanocytes without a significant change in the melanin content. MCP-1 treatment in normal human keratinocytes showed an increase in senescence-associated β-galactosidase staining and p53 and p21 protein expressions. In summary, MCP-1 may participate in the development of SL by affecting epidermal constituent cells, for example, by inducing melanocyte proliferation and keratinocyte senescence. View Full-Text
Keywords: solar lentigo; monocyte chemoattractant protein-1; epidermal constituent cells solar lentigo; monocyte chemoattractant protein-1; epidermal constituent cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lee, W.J.; Jo, S.Y.; Lee, M.H.; Won, C.H.; Lee, M.W.; Choi, J.H.; Chang, S.E. The Effect of MCP-1/CCR2 on the Proliferation and Senescence of Epidermal Constituent Cells in Solar Lentigo. Int. J. Mol. Sci. 2016, 17, 948.

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