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Int. J. Mol. Sci. 2016, 17(6), 816; doi:10.3390/ijms17060816

Applications of Fourier Transform Ion Cyclotron Resonance (FT-ICR) and Orbitrap Based High Resolution Mass Spectrometry in Metabolomics and Lipidomics

1
Department of Biological Sciences, College of Arts and Sciences, University of North Texas, Denton, TX 76203, USA
2
HighChem, Bratislava 81104, Slovakia
*
Author to whom correspondence should be addressed.
Academic Editor: Laszlo Prokai
Received: 1 April 2016 / Revised: 14 May 2016 / Accepted: 17 May 2016 / Published: 25 May 2016
(This article belongs to the Special Issue Fourier Transform Mass Spectrometry in Molecular Sciences)
View Full-Text   |   Download PDF [945 KB, uploaded 25 May 2016]   |  

Abstract

Metabolomics, along with other “omics” approaches, is rapidly becoming one of the major approaches aimed at understanding the organization and dynamics of metabolic networks. Mass spectrometry is often a technique of choice for metabolomics studies due to its high sensitivity, reproducibility and wide dynamic range. High resolution mass spectrometry (HRMS) is a widely practiced technique in analytical and bioanalytical sciences. It offers exceptionally high resolution and the highest degree of structural confirmation. Many metabolomics studies have been conducted using HRMS over the past decade. In this review, we will explore the latest developments in Fourier transform mass spectrometry (FTMS) and Orbitrap based metabolomics technology, its advantages and drawbacks for using in metabolomics and lipidomics studies, and development of novel approaches for processing HRMS data. View Full-Text
Keywords: high resolution mass spectrometry; metabolomics; lipidomics; FTMS; FT-ICR-MS; Orbitrap-MS; metabolomics data analysis high resolution mass spectrometry; metabolomics; lipidomics; FTMS; FT-ICR-MS; Orbitrap-MS; metabolomics data analysis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ghaste, M.; Mistrik, R.; Shulaev, V. Applications of Fourier Transform Ion Cyclotron Resonance (FT-ICR) and Orbitrap Based High Resolution Mass Spectrometry in Metabolomics and Lipidomics. Int. J. Mol. Sci. 2016, 17, 816.

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