Next Article in Journal
RVMAB: Using the Relevance Vector Machine Model Combined with Average Blocks to Predict the Interactions of Proteins from Protein Sequences
Next Article in Special Issue
MicroRNA-19b Downregulates Gap Junction Protein Alpha1 and Synergizes with MicroRNA-1 in Viral Myocarditis
Previous Article in Journal
Differential MicroRNA Expression Profile in Myxomatous Mitral Valve Prolapse and Fibroelastic Deficiency Valves
Previous Article in Special Issue
Managing Pancreatic Adenocarcinoma: A Special Focus in MicroRNA Gene Therapy
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2016, 17(5), 754; doi:10.3390/ijms17050754

MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis

1
Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona 60020, Italy
2
Mitochondria, Apoptosis and Cancer Research Group, School of Medical Science and Menzies Health Institute Queensland, Griffith University, Southport, QLD 4222, Australia
3
Molecular Therapy Group, Institute of Biotechnology, Czech Academy of Sciences, Prague-West 25243, Czech Republic
*
Authors to whom correspondence should be addressed.
Academic Editor: Y-h. Taguchi
Received: 31 March 2016 / Revised: 27 April 2016 / Accepted: 11 May 2016 / Published: 18 May 2016
(This article belongs to the Special Issue MicroRNA Regulation)
View Full-Text   |   Download PDF [616 KB, uploaded 18 May 2016]   |  

Abstract

The process of metabolic re-programing is linked to the activation of oncogenes and/or suppression of tumour suppressor genes, which are regulated by microRNAs (miRNAs). The interplay between oncogenic transformation-driven metabolic re-programming and modulation of aberrant miRNAs further established their critical role in the initiation, promotion and progression of cancer by creating a tumorigenesis-prone microenvironment, thus orchestrating processes of evasion to apoptosis, angiogenesis and invasion/migration, as well metastasis. Given the involvement of miRNAs in tumour development and their global deregulation, they may be perceived as biomarkers in cancer of therapeutic relevance. View Full-Text
Keywords: miRNAs; metabolic reprogramming; tumorigenesis; miR-126 and cancer-stroma environment; miRNA regulating signaling pathways miRNAs; metabolic reprogramming; tumorigenesis; miR-126 and cancer-stroma environment; miRNA regulating signaling pathways
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Tomasetti, M.; Amati, M.; Santarelli, L.; Neuzil, J. MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis. Int. J. Mol. Sci. 2016, 17, 754.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top