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Int. J. Mol. Sci. 2016, 17(5), 753; doi:10.3390/ijms17050753

Differential MicroRNA Expression Profile in Myxomatous Mitral Valve Prolapse and Fibroelastic Deficiency Valves

1
Cardiovascular Research Institute, National University Health System, Singapore 119228, Singapore
2
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
3
Department of Cardiology, Tan Tock Seng Hospital, Singapore 308433, Singapore
4
Department of Cardiology, National University Heart Centre, Singapore 119228, Singapore
5
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
6
Christchurch Heart Institute, University of Otago, Christchurch 8014, New Zealand
*
Author to whom correspondence should be addressed.
Academic Editors: Nalini Santanam and William Chi-shing Cho
Received: 19 February 2016 / Revised: 25 April 2016 / Accepted: 10 May 2016 / Published: 18 May 2016
(This article belongs to the Special Issue MicroRNA in Various Disease States as Biomarkers)
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Abstract

Myxomatous mitral valve prolapse (MMVP) and fibroelastic deficiency (FED) are two common variants of degenerative mitral valve disease (DMVD), which is a leading cause of mitral regurgitation worldwide. While pathohistological studies have revealed differences in extracellular matrix content in MMVP and FED, the molecular mechanisms underlying these two disease entities remain to be elucidated. By using surgically removed valvular specimens from MMVP and FED patients that were categorized on the basis of echocardiographic, clinical and operative findings, a cluster of microRNAs that expressed differentially were identified. The expressions of has-miR-500, -3174, -17, -1193, -646, -1273e, -4298, -203, -505, and -939 showed significant differences between MMVP and FED after applying Bonferroni correction (p < 0.002174). The possible involvement of microRNAs in the pathogenesis of DMVD were further suggested by the presences of in silico predicted target sites on a number of genes reported to be involved in extracellular matrix homeostasis and marker genes for cellular composition of mitral valves, including decorin (DCN), aggrecan (ACAN), fibromodulin (FMOD), α actin 2 (ACTA2), extracellular matrix protein 2 (ECM2), desmin (DES), endothelial cell specific molecule 1 (ESM1), and platelet/ endothelial cell adhesion molecule 1 (PECAM1), as well as inverse correlations of selected microRNA and mRNA expression in MMVP and FED groups. Our results provide evidence that distinct molecular mechanisms underlie MMVP and FED. Moreover, the microRNAs identified may be targets for the future development of diagnostic biomarkers and therapeutics. View Full-Text
Keywords: degererative mitral valve disease (DMVD); myxomatous mitral valve prolapse (MMVP); fibroelastic deficiency (FED); microRNA degererative mitral valve disease (DMVD); myxomatous mitral valve prolapse (MMVP); fibroelastic deficiency (FED); microRNA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chen, Y.-T.; Wang, J.; Wee, A.S.Y.; Yong, Q.-W.; Tay, E.L.-W.; Woo, C.C.; Sorokin, V.; Richards, A.M.; Ling, L.-H. Differential MicroRNA Expression Profile in Myxomatous Mitral Valve Prolapse and Fibroelastic Deficiency Valves. Int. J. Mol. Sci. 2016, 17, 753.

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