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Int. J. Mol. Sci. 2016, 17(5), 681; doi:10.3390/ijms17050681

Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells

1
Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan 717, Taiwan
2
School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
3
School of Traditional Chinese Medicine, Chang Gung University, Taoyuan 333, Taiwan
4
Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
5
Liver Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
6
Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Rolf Teschke
Received: 26 February 2016 / Revised: 22 April 2016 / Accepted: 26 April 2016 / Published: 6 May 2016
(This article belongs to the Section Bioactives and Nutraceuticals)
View Full-Text   |   Download PDF [694 KB, uploaded 6 May 2016]   |  

Abstract

Three new γ-ionylideneacetic acid derivatives, phellinulins A–C (1–3), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activated rat hepatic stellate cells and exhibited significant inhibition of hepatic fibrosis. View Full-Text
Keywords: ionone; Phellinus linteus; fungus; phellinulin; hepatic fibrosis ionone; Phellinus linteus; fungus; phellinulin; hepatic fibrosis
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MDPI and ACS Style

Huang, S.-C.; Kuo, P.-C.; Hung, H.-Y.; Pan, T.-L.; Chen, F.-A.; Wu, T.-S. Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells. Int. J. Mol. Sci. 2016, 17, 681.

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