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Int. J. Mol. Sci. 2016, 17(5), 681; doi:10.3390/ijms17050681

Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells

Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan 717, Taiwan
School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
School of Traditional Chinese Medicine, Chang Gung University, Taoyuan 333, Taiwan
Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
Liver Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan
Authors to whom correspondence should be addressed.
Academic Editor: Rolf Teschke
Received: 26 February 2016 / Revised: 22 April 2016 / Accepted: 26 April 2016 / Published: 6 May 2016
(This article belongs to the Section Bioactives and Nutraceuticals)
View Full-Text   |   Download PDF [694 KB, uploaded 6 May 2016]   |  


Three new γ-ionylideneacetic acid derivatives, phellinulins A–C (1–3), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activated rat hepatic stellate cells and exhibited significant inhibition of hepatic fibrosis. View Full-Text
Keywords: ionone; Phellinus linteus; fungus; phellinulin; hepatic fibrosis ionone; Phellinus linteus; fungus; phellinulin; hepatic fibrosis

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Huang, S.-C.; Kuo, P.-C.; Hung, H.-Y.; Pan, T.-L.; Chen, F.-A.; Wu, T.-S. Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells. Int. J. Mol. Sci. 2016, 17, 681.

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