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Int. J. Mol. Sci. 2016, 17(5), 650; doi:10.3390/ijms17050650

Interaction between Mesenchymal Stem Cells and B-Cells

Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, School of Medicine, First Affiliated Hospital, Zhejiang University, Hangzhou 310003, China
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Wenbin Deng
Received: 25 February 2016 / Revised: 19 April 2016 / Accepted: 19 April 2016 / Published: 5 May 2016
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Abstract

Mesenchymal stem cells (MSCs) are multipotent; non-hematopoietic stem cells. Because of their immunoregulatory abilities; MSCs are widely used for different clinical applications. Compared with that of other immune cells; the investigation of how MSCs specifically regulate B-cells has been superficial and insufficient. In addition; the few experimental studies on this regulation are often contradictory. In this review; we summarize the various interactions between different types or states of MSCs and B-cells; address how different types of MSCs and B-cells affect this interaction and examine how other immune cells influence the regulation of B-cells by MSCs. Finally; we hypothesize why there are conflicting results on the interaction between MSCs and B-cells in the literature. View Full-Text
Keywords: mesenchymal stem cell; B-cell; immune regulation; immune suppression; systemic lupus erythematous; graft-versus-host disease; T-cell; plasma cell; cytokine mesenchymal stem cell; B-cell; immune regulation; immune suppression; systemic lupus erythematous; graft-versus-host disease; T-cell; plasma cell; cytokine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Fan, L.; Hu, C.; Chen, J.; Cen, P.; Wang, J.; Li, L. Interaction between Mesenchymal Stem Cells and B-Cells. Int. J. Mol. Sci. 2016, 17, 650.

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