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Int. J. Mol. Sci. 2016, 17(4), 575; doi:10.3390/ijms17040575

Hybrid Macro-Porous Titanium Ornamented by Degradable 3D Gel/nHA Micro-Scaffolds for Bone Tissue Regeneration

1
Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Beijing 100730, China
2
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
3
Central Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Beijing 100730, China
4
Beijing Key Laboratory for Genetic Research of Bone and Joint Disease, No. 1 Shuaifuyuan, Beijing 100730, China
*
Author to whom correspondence should be addressed.
Academic Editor: Mohamed Rahaman
Received: 17 March 2016 / Revised: 5 April 2016 / Accepted: 11 April 2016 / Published: 15 April 2016
(This article belongs to the Section Biomaterial Sciences)
View Full-Text   |   Download PDF [4620 KB, uploaded 15 April 2016]   |  

Abstract

Porous titanium is a kind of promising material for bone substitution, while its bio-inert property results in demand of modifications to improve the osteointegration capacity. In this study, gelatin (Gel) and nano-hydroxyapatite (nHA) were used to construct 3D micro-scaffolds in the pores of porous titanium in the ratios of Gel:nHA = 1:0, Gel:nHA = 1:1, and Gel:nHA = 1:3, respectively. Cell attachment and proliferation, and gene and protein expression levels of osteogenic markers were evaluated in MC3T3-E1 cells, followed by bone regeneration assessment in a rabbit radius defect model. All hybrid scaffolds with different composition ratio were found to have significant promotional effects in cell adhesion, proliferation and differentiation, in which the group with Gel:nHA = 1:1 showed the best performance in vitro, as well as the most bone regeneration volume in vivo. This 3D micro-scaffolds modification may be an innovative method for porous titanium ornamentation and shows potential application values in clinic. View Full-Text
Keywords: porous titanium; Gel/nHA; 3D micro-scaffolds; hybrid scaffold; osteogenesis porous titanium; Gel/nHA; 3D micro-scaffolds; hybrid scaffold; osteogenesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yin, B.; Ma, P.; Chen, J.; Wang, H.; Wu, G.; Li, B.; Li, Q.; Huang, Z.; Qiu, G.; Wu, Z. Hybrid Macro-Porous Titanium Ornamented by Degradable 3D Gel/nHA Micro-Scaffolds for Bone Tissue Regeneration. Int. J. Mol. Sci. 2016, 17, 575.

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