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Int. J. Mol. Sci. 2016, 17(4), 568; doi:10.3390/ijms17040568

Prognostic Value of MicroRNAs in Preoperative Treated Rectal Cancer

1
Department of General, Visceral, and Pediatric Surgery, University Medical Center Göttingen, Robert-Koch-Str. 40, Göttingen 37075, Germany
2
Department of Medical Statistics, University Medical Center Göttingen, Robert-Koch-Str. 40, Göttingen 37075, Germany
3
Department of Pathology, University Medical Center Göttingen, Robert-Koch-Str. 40, Göttingen 37075, Germany
4
Department of Developmental Biochemistry, University of Göttingen, Göttingen 37075, Germany
5
Medical Practice Radiotherapy München, Burgstraße 7, München 80331, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Y-h. Taguchi
Received: 9 February 2016 / Revised: 1 April 2016 / Accepted: 6 April 2016 / Published: 15 April 2016
(This article belongs to the Special Issue MicroRNA Regulation)
View Full-Text   |   Download PDF [1048 KB, uploaded 15 April 2016]   |  

Abstract

Background: Patients with locally advanced rectal cancer are treated with preoperative chemoradiotherapy followed by surgical resection. Despite similar clinical parameters (uT2-3, uN+) and standard therapy, patients’ prognoses differ widely. A possible prediction of prognosis through microRNAs as biomarkers out of treatment-naïve biopsies would allow individualized therapy options. Methods: Microarray analysis of 45 microdissected preoperative biopsies from patients with rectal cancer was performed to identify potential microRNAs to predict overall survival, disease-free survival, cancer-specific survival, distant-metastasis-free survival, tumor regression grade, or nodal stage. Quantitative real-time polymerase chain reaction (qPCR) was performed on an independent set of 147 rectal cancer patients to validate relevant miRNAs. Results: In the microarray screen, 14 microRNAs were significantly correlated to overall survival. Five microRNAs were included from previous work. Finally, 19 miRNAs were evaluated by qPCR. miR-515-5p, miR-573, miR-579 and miR-802 demonstrated significant correlation with overall survival and cancer-specific survival (p < 0.05). miR-573 was also significantly correlated with the tumor regression grade after preoperative chemoradiotherapy. miR-133b showed a significant correlation with distant-metastasis-free survival. miR-146b expression levels showed a significant correlation with nodal stage. Conclusion: Specific microRNAs can be used as biomarkers to predict prognosis of patients with rectal cancer and possibly stratify patients’ therapy if validated in a prospective study. View Full-Text
Keywords: rectal cancer; prognosis; tumor regression grade; biomarkers; miRNA; chemoradiotherapy rectal cancer; prognosis; tumor regression grade; biomarkers; miRNA; chemoradiotherapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Azizian, A.; Epping, I.; Kramer, F.; Jo, P.; Bernhardt, M.; Kitz, J.; Salinas, G.; Wolff, H.A.; Grade, M.; Beißbarth, T.; Ghadimi, B.M.; Gaedcke, J. Prognostic Value of MicroRNAs in Preoperative Treated Rectal Cancer. Int. J. Mol. Sci. 2016, 17, 568.

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