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Open AccessCommunication
Int. J. Mol. Sci. 2016, 17(4), 564; doi:10.3390/ijms17040564

miRTargetLink—miRNAs, Genes and Interaction Networks

1
Chair for Clinical Bioinformatics, Saarland University, Saarbrücken D-66041, Germany
2
Department of Human Genetics, Saarland University, Homburg D-66421, Germany
3
Internal Medicine, Heidelberg University, Heidelberg D-69120, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Y-h. Taguchi
Received: 25 March 2016 / Revised: 6 April 2016 / Accepted: 7 April 2016 / Published: 14 April 2016
(This article belongs to the Special Issue MicroRNA Regulation)
View Full-Text   |   Download PDF [963 KB, uploaded 14 April 2016]   |  

Abstract

Information on miRNA targeting genes is growing rapidly. For high-throughput experiments, but also for targeted analyses of few genes or miRNAs, easy analysis with concise representation of results facilitates the work of life scientists. We developed miRTargetLink, a tool for automating respective analysis procedures that are frequently applied. Input of the web-based solution is either a single gene or single miRNA, but also sets of genes or miRNAs, can be entered. Validated and predicted targets are extracted from databases and an interaction network is presented. Users can select whether predicted targets, experimentally validated targets with strong or weak evidence, or combinations of those are considered. Central genes or miRNAs are highlighted and users can navigate through the network interactively. To discover the most relevant biochemical processes influenced by the target network, gene set analysis and miRNA set analysis are integrated. As a showcase for miRTargetLink, we analyze targets of five cardiac miRNAs. miRTargetLink is freely available without restrictions at www.ccb.uni-saarland.de/mirtargetlink. View Full-Text
Keywords: miRTargetkLink; miRNAs; genes; interaction networks miRTargetkLink; miRNAs; genes; interaction networks
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hamberg, M.; Backes, C.; Fehlmann, T.; Hart, M.; Meder, B.; Meese, E.; Keller, A. miRTargetLink—miRNAs, Genes and Interaction Networks. Int. J. Mol. Sci. 2016, 17, 564.

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