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Int. J. Mol. Sci. 2016, 17(4), 560; doi:10.3390/ijms17040560

RNase 7 in Cutaneous Defense

Department of Dermatology, University of Kiel, 24105 Kiel, Germany
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Ester Boix
Received: 16 March 2016 / Revised: 7 April 2016 / Accepted: 8 April 2016 / Published: 14 April 2016
(This article belongs to the Special Issue Antimicrobial RNases in Host Defense)
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Abstract

RNase 7 belongs to the RNase A superfamily and exhibits a broad spectrum of antimicrobial activity against various microorganisms. RNase 7 is expressed in human skin, and expression in keratinocytes can be induced by cytokines and microbes. These properties suggest that RNase 7 participates in innate cutaneous defense. In this review, we provide an overview about the role of RNase 7 in cutaneous defense with focus on the molecular mechanism of the antimicrobial activity of RNase 7, the regulation of RNase 7 expression, and the role of RNase 7 in skin diseases. View Full-Text
Keywords: RNase 7; cutaneous defense; antimicrobial peptides (AMPs) RNase 7; cutaneous defense; antimicrobial peptides (AMPs)
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Rademacher, F.; Simanski, M.; Harder, J. RNase 7 in Cutaneous Defense. Int. J. Mol. Sci. 2016, 17, 560.

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