Next Article in Journal
Deficiency of Senescence Marker Protein 30 Exacerbates Cardiac Injury after Ischemia/Reperfusion
Next Article in Special Issue
The Relationship between NALP3 and Autoinflammatory Syndromes
Previous Article in Journal
Exploring the Interaction Natures in Plutonyl (VI) Complexes with Topological Analyses of Electron Density
Previous Article in Special Issue
Arginine Metabolism in Bacterial Pathogenesis and Cancer Therapy
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2016, 17(4), 541; doi:10.3390/ijms17040541

Fidelity in Animal Modeling: Prerequisite for a Mechanistic Research Front Relevant to the Inflammatory Incompetence of Acute Pediatric Malnutrition

Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
Academic Editor: Marcello Iriti
Received: 17 March 2016 / Revised: 5 April 2016 / Accepted: 6 April 2016 / Published: 11 April 2016
(This article belongs to the Collection Feature Annual Reviews in Molecular Sciences)
View Full-Text   |   Download PDF [232 KB, uploaded 11 April 2016]

Abstract

Inflammatory incompetence is characteristic of acute pediatric protein-energy malnutrition, but its underlying mechanisms remain obscure. Perhaps substantially because the research front lacks the driving force of a scholarly unifying hypothesis, it is adrift and research activity is declining. A body of animal-based research points to a unifying paradigm, the Tolerance Model, with some potential to offer coherence and a mechanistic impetus to the field. However, reasonable skepticism prevails regarding the relevance of animal models of acute pediatric malnutrition; consequently, the fundamental contributions of the animal-based component of this research front are largely overlooked. Design-related modifications to improve the relevance of animal modeling in this research front include, most notably, prioritizing essential features of pediatric malnutrition pathology rather than dietary minutiae specific to infants and children, selecting windows of experimental animal development that correspond to targeted stages of pediatric immunological ontogeny, and controlling for ontogeny-related confounders. In addition, important opportunities are presented by newer tools including the immunologically humanized mouse and outbred stocks exhibiting a magnitude of genetic heterogeneity comparable to that of human populations. Sound animal modeling is within our grasp to stimulate and support a mechanistic research front relevant to the immunological problems that accompany acute pediatric malnutrition. View Full-Text
Keywords: acute malnutrition; protein-energy malnutrition; protein-calorie malnutrition; childhood malnutrition; low-protein diet; caloric restriction; animal model; immune depression; cell-mediated immune depression acute malnutrition; protein-energy malnutrition; protein-calorie malnutrition; childhood malnutrition; low-protein diet; caloric restriction; animal model; immune depression; cell-mediated immune depression
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Woodward, B. Fidelity in Animal Modeling: Prerequisite for a Mechanistic Research Front Relevant to the Inflammatory Incompetence of Acute Pediatric Malnutrition. Int. J. Mol. Sci. 2016, 17, 541.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top