Next Article in Journal
A New Secondary Structure Assignment Algorithm Using Cα Backbone Fragments
Next Article in Special Issue
Fidelity in Animal Modeling: Prerequisite for a Mechanistic Research Front Relevant to the Inflammatory Incompetence of Acute Pediatric Malnutrition
Previous Article in Journal
Effects of Two Sublethal Concentrations of Mercury Chloride on the Morphology and Metallothionein Activity in the Liver of Zebrafish (Danio rerio)
Previous Article in Special Issue
Endocannabinoids as Guardians of Metastasis
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2016, 17(3), 363; doi:10.3390/ijms17030363

Arginine Metabolism in Bacterial Pathogenesis and Cancer Therapy

1
Department of Microbiology, The University of Hong Kong, Hong Kong, China
2
Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, China
3
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China
4
Faculty of Dentistry, The University of Hong Kong, Hong Kong, China
5
Department of Pathology, The University of Hong Kong, Hong Kong, China
6
State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong, China
7
Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Helmut Segner
Received: 29 December 2015 / Revised: 29 January 2016 / Accepted: 4 March 2016 / Published: 11 March 2016
(This article belongs to the Collection Feature Annual Reviews in Molecular Sciences)
View Full-Text   |   Download PDF [1337 KB, uploaded 11 March 2016]   |  

Abstract

Antibacterial resistance to infectious diseases is a significant global concern for health care organizations; along with aging populations and increasing cancer rates, it represents a great burden for government healthcare systems. Therefore, the development of therapies against bacterial infection and cancer is an important strategy for healthcare research. Pathogenic bacteria and cancer have developed a broad range of sophisticated strategies to survive or propagate inside a host and cause infection or spread disease. Bacteria can employ their own metabolism pathways to obtain nutrients from the host cells in order to survive. Similarly, cancer cells can dysregulate normal human cell metabolic pathways so that they can grow and spread. One common feature of the adaption and disruption of metabolic pathways observed in bacterial and cancer cell growth is amino acid pathways; these have recently been targeted as a novel approach to manage bacterial infections and cancer therapy. In particular, arginine metabolism has been illustrated to be important not only for bacterial pathogenesis but also for cancer therapy. Therefore, greater insights into arginine metabolism of pathogenic bacteria and cancer cells would provide possible targets for controlling of bacterial infection and cancer treatment. This review will summarize the recent progress on the relationship of arginine metabolism with bacterial pathogenesis and cancer therapy, with a particular focus on arginase and arginine deiminase pathways of arginine catabolism. View Full-Text
Keywords: arginine metabolism; arginase; arginine deiminase; bacterial pathogenesis; cancer therapy arginine metabolism; arginase; arginine deiminase; bacterial pathogenesis; cancer therapy
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Xiong, L.; Teng, J.L.L.; Botelho, M.G.; Lo, R.C.; Lau, S.K.P.; Woo, P.C.Y. Arginine Metabolism in Bacterial Pathogenesis and Cancer Therapy. Int. J. Mol. Sci. 2016, 17, 363.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top