Next Article in Journal
RORC2 Genetic Variants and Serum Levels in Patients with Rheumatoid Arthritis
Previous Article in Journal
High Salt Diet Affects Renal Sodium Excretion and ERRα Expression
Previous Article in Special Issue
Iron in Multiple Sclerosis and Its Noninvasive Imaging with Quantitative Susceptibility Mapping
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2016, 17(4), 489; doi:10.3390/ijms17040489

Individual Assessment of Brain Tissue Changes in MS and the Effect of Focal Lesions on Short-Term Focal Atrophy Development in MS: A Voxel-Guided Morphometry Study

1
Universitätsmedizin Mannheim, Department of Neurology, Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany
2
Hospital zum Heiligen Geist, Department for Early Rehabilitation, Kempen 47906, Germany
3
Institute for Anatomy, Heinrich-Heine-University Düsseldorf, Universitätsstr. 1, Düsseldorf 40001, Germany
4
Deutsches Institut für Medizinische Dokumentation und Information, Waisenhausgasse 36-38a, Köln 50676, Germany
5
Fraunhofer MEVIS, Institut für Bildgestützte Medizin, Universitätsallee 29, Bremen 28359, Germany
6
Department of Biometry and Statistics, Medical Faculty Mannheim, Ruprecht-Karls University Heidelberg, Mannheim 68167, Germany
7
MIAC, Basel, Universitätsspital Basel, Mittlere Strasse 83, Basel 4056, Switzerland
8
Neurology, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel, Petersgraben 4, Basel 4052, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Christoph Kleinschnitz
Received: 17 August 2015 / Revised: 22 February 2016 / Accepted: 25 February 2016 / Published: 1 April 2016
(This article belongs to the Special Issue Advances in Multiple Sclerosis)
View Full-Text   |   Download PDF [3994 KB, uploaded 1 April 2016]   |  

Abstract

We performed voxel-guided morphometry (VGM) investigating the mechanisms of brain atrophy in multiple sclerosis (MS) related to focal lesions. VGM maps detect regional brain changes when comparing 2 time points on high resolution T1-weighted (T1w) magnetic resonace imaging (MRI). Two T1w MR datasets from 92 relapsing-remitting MS patients obtained 12 months apart were analysed with VGM. New lesions and volume changes of focal MS lesions as well as in the surrounding tissue were identified by visual inspection on colour coded VGM maps. Lesions were dichotomized in active and inactive lesions. Active lesions, defined by either new lesions (NL) (volume increase > 5% in VGM), chronic enlarging lesions (CEL) (pre-existent T1w lesions with volume increase > 5%), or chronic shrinking lesions (CSL) (pre-existent T1w lesions with volume reduction > 5%) in VGM, were accompanied by tissue shrinkage in surrounding and/or functionally related regions. Volume loss within the corpus callosum was highly correlated with the number of lesions in its close proximity. Volume loss in the lateral geniculate nucleus was correlated with lesions along the optic radiation. VGM analysis provides strong evidence that all active lesion types (NL, CEL, and CSL) contribute to brain volume reduction in the vicinity of lesions and/or in anatomically and functionally related areas of the brain. View Full-Text
Keywords: regional brain atrophy; multiple sclerosis; voxel; lesion; corpus callosum; lateral geniculate nucleus; shrinking; retrograde degeneration; Wallerian degeneration regional brain atrophy; multiple sclerosis; voxel; lesion; corpus callosum; lateral geniculate nucleus; shrinking; retrograde degeneration; Wallerian degeneration
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Fox, J.; Kraemer, M.; Schormann, T.; Dabringhaus, A.; Hirsch, J.; Eisele, P.; Szabo, K.; Weiss, C.; Amann, M.; Weier, K.; Naegelin, Y.; Kappos, L.; Gass, A. Individual Assessment of Brain Tissue Changes in MS and the Effect of Focal Lesions on Short-Term Focal Atrophy Development in MS: A Voxel-Guided Morphometry Study. Int. J. Mol. Sci. 2016, 17, 489.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top