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Int. J. Mol. Sci. 2016, 17(4), 480; doi:10.3390/ijms17040480

High Salt Diet Affects Renal Sodium Excretion and ERRα Expression

Department of Cardiovascular Medicine, First Affiliated Hospital of Medical College of Xi’an Jiaotong University, Key Laboratory of Molecular Cardiology, No. 277 Yanta West Road, Xi’an 710061, China
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Academic Editor: Anastasia Susie Mihailidou
Received: 29 February 2016 / Revised: 24 March 2016 / Accepted: 25 March 2016 / Published: 1 April 2016
(This article belongs to the Special Issue Molecular Research on Hypertension)
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Abstract

Kidneys regulate the balance of water and sodium and therefore are related to blood pressure. It is unclear whether estrogen-related receptor α (ERRα), an orphan nuclear receptor and transcription factor highly expressed in kidneys, affects the reabsorption of water and sodium. The aim of this study was to determine whether changes in the expressions of ERRα, Na+/K+-ATPase and epithelial sodium channel (ENaC) proteins affected the reabsorption of water and sodium in kidneys of Dahl salt-sensitive (DS) rats. SS.13BN rats, 98% homologous to the DS rats, were used as a normotensive control group. The 24 h urinary sodium excretion of the DS and SS.13BN rats increased after the 6-week high salt diet intervention, while sodium excretion was increased in DS rats with daidzein (agonist of ERRα) treatment. ERRα expression was decreased, while β- and γ-ENaC mRNA expressions were increased upon high sodium diet treatment in the DS rats. In the chromatin immunoprecipitation (CHIP) assay, positive PCR signals were obtained in samples treated with anti-ERRα antibody. The transcriptional activity of ERRα was decreased upon high salt diet intervention. ERRα reduced the expressions of β- and γ-ENaC by binding to the ENaC promoter, thereby increased Na+ reabsorption. Therefore, ERRα might be one of the factors causing salt-sensitive hypertension. View Full-Text
Keywords: sodium; potassium; estrogen-related receptor α; salt sensitive sodium; potassium; estrogen-related receptor α; salt sensitive
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MDPI and ACS Style

Wang, D.; Wang, Y.; Liu, F.-Q.; Yuan, Z.-Y.; Mu, J.-J. High Salt Diet Affects Renal Sodium Excretion and ERRα Expression. Int. J. Mol. Sci. 2016, 17, 480.

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