Anti-Apoptotic and Pro-Survival Effect of Alpinate Oxyphyllae Fructus (AOF) in a d-Galactose-Induced Aging Heart
Abstract
:1. Introduction
2. Results
2.1. Echocardiography Findings
2.2. Cardiac Histopathological Changes
2.3. TUNEL-Positive Cells Detection in Cardiac Tissues
2.4. Alpinate Oxyphyllae Fructus (AOF) Treatment Attenuated the Activation of Cardiac Fas Receptor-Dependent Apoptotic Pathways
2.5. Effect of AOF Treatment on Cardiac Survival Pathways
3. Discussion
4. Materials and Methods
4.1. AOF Extraction
4.2. Animals and Experimental Design
4.3. Echocardiography
4.4. Hematoxylin–Eosin (H & E) Staining
4.5. Immunohistochemistry
4.6. 4,6-Diamidino-2-phenylindole (DAPI) and Tunnel Staining
4.7. Tissue Extraction
4.8. Electrophoresis and Western Blot
4.9. Statistical Analysis
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Echocardiographic Parameters | Control | Aging | Aging + AL | Aging + AM | Aging + AH |
---|---|---|---|---|---|
n = 3 | n = 3 | n = 3 | n = 3 | n = 3 | |
EF (Teich) (%) | 75.88 ± 6.58 | 67.46 ± 2.70 | 76.96 ± 2.86 ## | 71.53 ± 0.77 # | 80.56 ± 3.79 ### |
FS (%) | 40.44 ± 5.83 | 33.61 ± 2.02 | 41.12 ± 2.61 ## | 36.52 ± 0.58 | 44.75 ± 3.92 ## |
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Chang, Y.-M.; Chang, H.-H.; Kuo, W.-W.; Lin, H.-J.; Yeh, Y.-L.; Padma Viswanadha, V.; Tsai, C.-C.; Chen, R.-J.; Chang, H.-N.; Huang, C.-Y. Anti-Apoptotic and Pro-Survival Effect of Alpinate Oxyphyllae Fructus (AOF) in a d-Galactose-Induced Aging Heart. Int. J. Mol. Sci. 2016, 17, 466. https://doi.org/10.3390/ijms17040466
Chang Y-M, Chang H-H, Kuo W-W, Lin H-J, Yeh Y-L, Padma Viswanadha V, Tsai C-C, Chen R-J, Chang H-N, Huang C-Y. Anti-Apoptotic and Pro-Survival Effect of Alpinate Oxyphyllae Fructus (AOF) in a d-Galactose-Induced Aging Heart. International Journal of Molecular Sciences. 2016; 17(4):466. https://doi.org/10.3390/ijms17040466
Chicago/Turabian StyleChang, Yung-Ming, Hen-Hong Chang, Wei-Wen Kuo, Hung-Jen Lin, Yu-Lan Yeh, Vijaya Padma Viswanadha, Chin-Chuan Tsai, Ray-Jade Chen, Hsin-Nung Chang, and Chih-Yang Huang. 2016. "Anti-Apoptotic and Pro-Survival Effect of Alpinate Oxyphyllae Fructus (AOF) in a d-Galactose-Induced Aging Heart" International Journal of Molecular Sciences 17, no. 4: 466. https://doi.org/10.3390/ijms17040466