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Int. J. Mol. Sci. 2016, 17(3), 428; doi:10.3390/ijms17030428

Targeted Delivery Systems for Molecular Therapy in Skeletal Disorders

Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
These authors contributed equally to this work.
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Authors to whom correspondence should be addressed.
Academic Editor: Ritva Tikkanen
Received: 28 November 2015 / Revised: 10 March 2016 / Accepted: 14 March 2016 / Published: 22 March 2016
View Full-Text   |   Download PDF [576 KB, uploaded 22 March 2016]   |  

Abstract

Abnormalities in the integral components of bone, including bone matrix, bone mineral and bone cells, give rise to complex disturbances of skeletal development, growth and homeostasis. Non-specific drug delivery using high-dose systemic administration may decrease therapeutic efficacy of drugs and increase the risk of toxic effects in non-skeletal tissues, which remain clinical challenges in the treatment of skeletal disorders. Thus, targeted delivery systems are urgently needed to achieve higher drug delivery efficiency, improve therapeutic efficacy in the targeted cells/tissues, and minimize toxicities in non-targeted cells/tissues. In this review, we summarize recent progress in the application of different targeting moieties and nanoparticles for targeted drug delivery in skeletal disorders, and also discuss the advantages, challenges and perspectives in their clinical translation. View Full-Text
Keywords: targeted delivery systems; skeletal disorders; targeting moieties; nanoparticles targeted delivery systems; skeletal disorders; targeting moieties; nanoparticles
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Dang, L.; Liu, J.; Li, F.; Wang, L.; Li, D.; Guo, B.; He, X.; Jiang, F.; Liang, C.; Liu, B.; Badshah, S.A.; He, B.; Lu, J.; Lu, C.; Lu, A.; Zhang, G. Targeted Delivery Systems for Molecular Therapy in Skeletal Disorders. Int. J. Mol. Sci. 2016, 17, 428.

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