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Int. J. Mol. Sci. 2016, 17(3), 423; doi:10.3390/ijms17030423

A Review of Ribonuclease 7’s Structure, Regulation, and Contributions to Host Defense

1
Center for Clinical and Translational Research, The Research Institute at Nationwide Children’s, Columbus, OH 43205, USA
2
Division of Pediatric Nephrology, Nationwide Children’s, Columbus, OH 43205, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Ester Boix
Received: 13 February 2016 / Revised: 16 March 2016 / Accepted: 18 March 2016 / Published: 22 March 2016
(This article belongs to the Special Issue Antimicrobial RNases in Host Defense)
View Full-Text   |   Download PDF [1308 KB, uploaded 22 March 2016]   |  

Abstract

The Ribonuclease A Superfamily is composed of a group of structurally similar peptides that are secreted by immune cells and epithelial tissues. Several members of the Ribonuclease A Superfamily demonstrate antimicrobial activity, and it has been suggested that some of these ribonucleases play an essential role in host defense. Ribonuclease 7 (RNase 7) is an epithelial-derived secreted peptide with potent broad-spectrum antimicrobial activity. This review summarizes the published literature on RNase 7’s antimicrobial properties, structure, regulation, and contributions to host defense. In doing so, we conclude by highlighting key knowledge gaps that must be investigated to completely understand the potential of developing RNase 7 as a novel therapeutic for human infectious diseases. View Full-Text
Keywords: ribonuclease; antimicrobial peptides; ribonuclease 7; innate immunity; infection; host defense ribonuclease; antimicrobial peptides; ribonuclease 7; innate immunity; infection; host defense
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Becknell, B.; Spencer, J.D. A Review of Ribonuclease 7’s Structure, Regulation, and Contributions to Host Defense. Int. J. Mol. Sci. 2016, 17, 423.

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